Platelets regulate glioblastoma growth and immunity via sex-dependent PAR4 - Estrogen receptor beta signaling
Anthony R. Sloan, George Bukenya, Gavin P. Tannish, Daniel J. Silver, Anu Aggarwal, Juyeun Lee, Daniel Rosoff, Tyler J. Alban, Ivan Juric, Shikha Parsai, Vargab Baruah, Tyler Bodovetz, Donovan Whitfield, Liza Tack, Tanvi Navadgi, , Justin Durla Lathia
This study shows that platelet PAR4 signaling, interacting with estrogen receptor beta, drives glioblastoma progression and immune suppression, with sex-specific effects on survival and TME dynamics.
Cancer Cell · Oct 1, 2026Peer-reviewedCancer Biology