Justin Durla Lathia

This paper shows that combining GLP1R agonists with vorasidenib induces synergistic cytotoxicity in mIDH glioma by generating peroxynitrite through mitochondrial redox metabolism.

This study shows that platelet PAR4 signaling, interacting with estrogen receptor beta, drives glioblastoma progression and immune suppression, with sex-specific effects on survival and TME dynamics.

This study shows GABA receptor B signaling promotes GBM growth in females through immune mechanisms, with sex-specific effects on survival and treatment outcomes.

This study develops triazole-based WDR5 inhibitors that show improved brain penetration and antiproliferative activity against glioblastoma CSCs, with synergistic effects when combined with ATAD2 inhibitors.

The paper identifies OR2L13 agonists that reduce platelet reactivity and thrombosis by depolymerizing the actin cytoskeleton through HSP27 phosphorylation.

This study identifies MIF-CD74 axis regulation of myeloid cells in gliomas and shows that MIF inhibition enhances immune therapy efficacy in wtIDH1 gliomas.

This study shows that Cx43 promotes glioblastoma cancer stem cell survival and self-renewal via a WNK1-c-MYC signaling pathway.

This study identifies ABHD6 as a therapeutic target in MASLD-related HCC by showing its role in lysosomal lipid remodeling and tumor progression.

This study shows that spermidine, a metabolite from glioblastoma cells, suppresses CD8+ T cell function, promoting tumor growth and poor patient outcomes.

This study identifies miR-644a as a tumor cell-intrinsic mediator of sex bias in glioblastoma, showing it is more highly expressed in females and its target genes are linked to poorer survival.

This study shows that blocking CSPG production and the receptor PTPσ improves functional recovery in chronic spinal cord injury models.

The paper identifies conserved adhesion genes involved in glioblastoma invasion by screening Drosophila border cell migration and analyzing their expression in human glioblastoma tumors.

The paper examines sex differences in COVID-19 outcomes and immune responses using single-cell RNA-sequencing and clinical data, finding higher risk for males and potential mechanisms for sex-specific treatments.

This study identifies disease mutations that perturb protein-protein interactions in the human 3D interactome, showing their association with cancer survival and drug response.