A Suite of Biochemical and Cell-Based Assays for the Characterization of KRAS Inhibitors and Degraders
Medhanie Kidane, Rene M. Hoffman, Jennifer K. Wolfe-Demarco…·Jean A. Bernatchez
The paper develops biochemical and cell-based assays to evaluate KRAS inhibitors and degraders, generating selectivity profiles and dissociation constants for various KRAS mutants.