Author

Charlie Clapp

Scripps Research Institute

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Approach:experimental assay· 1 Organism:mouse· 1

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Eros Lazzerini DenchiiD· 1 shared Robert She· 1 shared

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Molecular BiologybioRxivPreprintMay 30, 2018

POT1a depletion in the developing brain leads to p53-dependent neuronal cell death and ataxia.

Robert She, Charlie Clapp, Eros Lazzerini Denchi

This study shows that POT1a depletion in neural progenitors causes p53-dependent neuronal death and ataxia, while p53 inactivation rescues lethality, highlighting distinct DNA damage response pathways in neurological disorders.

DOI 10.1101/335059

mouseexperimental assay

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