Synthetic BiologybioRxivPreprint
Systematically investigating the key features of the nuclease deactivated Cpf1 for tunable multiplex genetic regulation
Chensi Miao, Huiwei Zhao, Long Qian, Chunbo Lou
This study identifies key features of nuclease-deactivated Cpf1 for multiplex gene regulation, including novel PAM patterns and improved gene repression through crRNA modifications.
DOI 10.1101/297903