Long Qian

The paper constructs a DNA methylation atlas for 106 Chinese individuals using nanopore long-read sequencing, identifying CpG sites and environmental influences on methylation.

This study investigates FUS-ERG fusion oncoprotein-DNA co-condensates, revealing nested asymmetric phase separation and their potential for DNA-based information manipulation.

The paper develops a framework to trace siderophore biosynthesis to primary metabolism and applies it to identify metabolic differences between beneficial and pathogenic bacteria.

gcSV is a structural variant detection framework that improves accuracy and yield across long, hybrid, and short-read data, identifying over 93,000 novel SVs.

This paper introduces a DNA-based data storage method using epigenetic modifications, achieving scalable and parallel data writing and retrieval.

SIDERITE identifies new iron-binding molecules by analyzing chemical structures and confirming their iron-binding ability through experimental validation.

This study introduces a method to improve DNA data storage efficiency by using neural networks and language models to generate constraint-free sequences, achieving 12%-26% better compression and reducing synthesis costs.

The paper introduces a standardized NRPS architecture using conserved motifs, leading to new subtype classifications, novel motifs, and insights into reengineering challenges.

This study shows that breaking DNA-cell size scaling in E. coli leads to a linear growth regime and resource reallocation to plasmid-borne gene expression.

This study identifies key features of nuclease-deactivated Cpf1 for multiplex gene regulation, including novel PAM patterns and improved gene repression through crRNA modifications.