Cell BiologybioRxiv
Hepatocyte nuclear factor 4-mediated lipotoxicity provokes mitochondrial damage in peroxisome-deficient pex19 mutants
Margret Helene Buelow, Julia Sellin, Christian Wingen…·Michael Hoch
This study identifies Hnf4-mediated lipotoxicity as a mechanism causing mitochondrial damage in pex19 mutants, showing that reducing Hnf4 rescues mitochondrial function and survival.
DOI 10.1091/mbc.e17-08-0535