Author

Chuangye Qi

Baylor College of Medicine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cell-cell communication· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

Hui ZhengiD· 3 shared Shuo WangiD· 3 shared Chetan Singh RajpurohitiD· 2 shared Hongjie LiiD· 2 shared Anamitra GhoshiD· 1 shared Baijayanti Ghosh· 1 shared Baiping WangiD· 1 shared Chonghui ChengiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersNeuroscience

Hui ZhengORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Astrocytic sEH-EET signaling regulates microglial lysosomal function and suppresses the STING-Type I interferon pathway in Alzheimer's disease

Baijayanti Ghosh, Shuo Wang, Chuangye Qi, Anamitra Ghosh, Michele M. Comerota, Chetan Singh Rajpurohit, Darryl C. Zeldin, Hui Zheng

This study identifies an astrocyte-microglia signaling axis in Alzheimer's disease where astrocytic sEH limits EET availability, promoting lysosomal clearance of pSTING and suppressing type I IFN signaling.

bioRxiv · Oct 20, 2026 · PreprintNeuroscience

Astrocyte cell-surface proteomics identified CD44 as an OPN/SPP1 receptor regulating lipid metabolism and glial crosstalk in Alzheimer s disease

Omar Peña-Ramos, Manasee Gedam, Xue Zhang, Shuo Wang, Chuangye Qi, Tzu-Hsuan Huang, Chetan Singh Rajpurohit, Mikayla Dunlap, Yu Deng, Nicole Auld, Sung Yun Jung, Hongjie Li, Jun Li, Liqun Luo, Junmin Peng, , Hui Zheng

The paper identifies CD44 as an OPN receptor in astrocytes that regulates lipid metabolism and glial communication in Alzheimer's disease.

bioRxiv · Dec 9, 2025 · PreprintNeuroscience

TFEB-vacuolar ATPase signaling regulates lysosomal function and microglial activation in tauopathy

Baiping Wang, Heidi Martini‐Stoica, Chuangye Qi, Tzu‐Chiao Lu, Shuo Wang, Wen Xiong, Yanyan Qi, Yin Xu, Marco Sardiello, Hongjie Li, Hui Zheng

This study shows that TFEB-v-ATPase signaling regulates lysosomal function and microglial activation in tauopathy by impairing lysosomal acidification and altering microglia responses.

Nature Neuroscience · Nov 20, 2023Peer-reviewedNeuroscience

SARS-CoV-2 Restructures the Host Chromatin Architecture

Ruoyu Wang, Joo‐Hyung Lee, Feng Xiong, Jieun Kim, Lana Al Hasani, Xiaoyi Yuan, Pooja Shivshankar, Joanna Krakowiak, Chuangye Qi, Yanyu Wang, Holger K. Eltzschig, Wenbo Li

This study investigates how SARS-CoV-2 alters host chromatin architecture and epigenome, revealing disruptions in 3D genome structure and transcriptional regulation of immune-related genes.

bioRxiv · Jul 20, 2021 · PreprintMolecular Biology