NeurosciencebioRxivPreprint
Astrocytic sEH-EET signaling regulates microglial lysosomal function and suppresses the STING-Type I interferon pathway in Alzheimer's disease
Baijayanti Ghosh, Shuo Wang, Chuangye Qi…·Hui Zheng
This study identifies an astrocyte-microglia signaling axis in Alzheimer's disease where astrocytic sEH limits EET availability, promoting lysosomal clearance of pSTING and suppressing type I IFN signaling.