Wenbo Li

The paper identifies pre-established chromatin regions in human ESCs that enable rapid activation of lineage-specific genes during differentiation.

The paper develops a general AI model that integrates diverse genomic modalities and knowledge, showing strong performance across cell types and tissues.

This study generates region-specific airway basal stem cells from human pluripotent stem cells by modulating the NOGGIN-BMP axis, showing distinct differentiation potentials for proximal and distal airway cell types.

This study shows that non-mutated human tau causes neurodegeneration in a microglia-dependent manner in a mouse model of Alzheimer's disease.

This study identifies a unique mutational signature, SBS87, in testicular germ cell tumors (TGCTs) that resembles thiopurine-induced DNA damage and is associated with tumor latency and telomere elongation.

The paper identifies AD-associated changes in m6A methylation on promoter antisense RNAs and shows their role in regulating gene expression and neuronal survival in Alzheimer's disease.

The paper shows that phosphorylated CTCF binds the SIRT1 promoter under oxidative stress, activating a cardioprotective transcriptional program in cardiomyocytes.

This study identifies a novel FXR-induced eRNA, FincoR, which mediates the therapeutic effects of hammerhead-type FXR agonists in NASH mice.

This study investigates how chromatin-associated RNA interacts with 3D genome organization in human cells, revealing a feedback loop between RNA distribution and chromatin structure.

This study investigates how SARS-CoV-2 alters host chromatin architecture and epigenome, revealing disruptions in 3D genome structure and transcriptional regulation of immune-related genes.

This study investigates 3D genome reorganization during mouse spermatogenesis, revealing dynamic changes in TADs, chromatin loops, and transcriptional regulation.