Mansun Law

This study identifies the conserved bridging domain on HCV E1E2 as a target for neutralizing antibodies from diverse lineages, showing additivity with neutralizing face antibodies.

This study identifies structural features of HCV E2 glycoprotein recognized by germline B cell receptors and evaluates strategies to enhance germline antibody interactions.

This study identifies two classes of HCV E2 neutralizing antibodies from non-human primates immunized with a recombinant E1E2, showing similarity to human antibodies.

The paper designs, characterizes, and tests a soluble HCV E1E2 heterodimer and self-assembling nanoparticles for vaccine development.

scFPC-DE identifies temporally differentially expressed genes along single-cell trajectories by modeling gene expression as functions of pseudotime and using functional principal component analysis to capture shared covariance structures.

This study shows that B cells in hepatitis C patients retain dysregulated transcriptional profiles after cure, with sustained TNF signaling driving chronic inflammation and loss of protective memory.

The paper curates high-quality human immunoglobulin germline gene reference sets to improve AIRR-seq analysis accuracy and facilitate immunoglobulin gene studies.

The paper explores immune orthogonality among protein orthologs by analyzing CRISPR-Cas9 and AAV serotypes, finding high immune orthogonality in Cas9 but not in AAVs.