Author

Cristina R. Hofman

The University of Texas Southwestern Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:differential expression· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

David R. CoreyiD· 3 shared Jiaxin HuiD· 3 shared Victor Tse· 2 shared Audrius Kilikevičius· 1 shared Georgios KaragkounisiD· 1 shared Jill M. WestcottiD· 1 shared Jon Graswich· 1 shared Krystal C. JohnsoniD· 1 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersBiochemistry

David R. CoreyORCID

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3 papers

Recent·Most cited

BiochemistrybioRxivPreprintMay 8, 2025

Nuclear Argonaute:miRNA complexes recognize target sequences within chromatin and silence gene expression

Cristina R. Hofman, Jiaxin Hu, Rut Bryl…·David R. Corey

This study identifies nuclear miRNA:Argonaute complexes and their chromatin-associated RNA targets, showing miRNA-mediated gene silencing occurs in both nucleus and cytoplasm.

DOI 10.1101/2025.05.08.652285

humanChIP-seq

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BiochemistrybioRxivPreprintMay 7, 2025

Small molecule inhibition of CPSF3 impacts R-loop distribution

Cristina R. Hofman, Victor Tse, Jiaxin Hu, David R. Corey

The paper tests the effect of CPSF3 inhibitors YT-II-100 and JTE-607 on R-loop formation, finding global increases but no effect on specific R-loop positive control genes.

1 citation

experimental assay

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BiochemistryNucleic Acids ResearchPeer-reviewedDec 18, 2023

Nuclear Localization of Argonaute is affected by Cell Density and May Relieve Repression by microRNAs

Krystal C. Johnson, Audrius Kilikevičius, Cristina R. Hofman…·David R. Corey

This study shows that nuclear localization of AGO2 in HCT116 cells and human colon tumors can de-repress miRNA targets and enhance cell migration, influenced by cell density, miRNA biogenesis, and miRISC components.

33 citations

humanbulk RNA-seq

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