Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumors
S. Hegde, B. Giotti, B. Y. Soong, L. Halasz, J. Le Berichel, A. Magen, B. Kloeckner, R. Mattiuz, M. D. Park, A. Marks, M. Belabed, P. Hamon, T. Chin, L. Troncoso, J. J. Lee, , M. Merad
The paper identifies NRF2-driven myeloid progenitor dysregulation that sustains immunosuppressive macrophages in tumors, showing NRF2 inhibition reduces their survival and enhances antitumor immunity.
bioRxiv · Jun 24, 2024Immunology