S. Hegde

Single cell view of tumor microenvironment gradients in pleural mesothelioma

This paper uses single-cell RNA-sequencing to analyze the tumor microenvironment in pleural mesothelioma, identifying gene programs, fetal-like endothelial cells, and a new therapeutic target.

MobileLAMP: A portable, low-cost, open-source device for isothermal nucleic acid amplification

The paper introduces MobileLAMP, an open-source, low-cost device for isothermal nucleic acid amplification, demonstrating its effectiveness with colorimetric LAMP for RNA and DNA targets.

Glutamylation of Npm2 and Nap1 acidic disordered regions increases DNA charge mimicry to enhance chaperone efficiency

The paper shows that glutamylation of acidic IDRs in Npm2 and Nap1 enhances their DNA mimicry function, improving histone chaperone efficiency in nucleosome assembly.

Single-cell immune multi-omics and repertoire analyses in pancreatic ductal adenocarcinoma reveal differential immunosuppressive mechanisms within different tumour microenvironments

The paper analyzes single-cell immune multi-omics data from PDAC to identify differential immunosuppressive mechanisms in distinct tumour microenvironments.

Interkingdom interactions shape the fungal microbiome of mosquitoes

This study investigates the fungal microbiome of three mosquito species, finding environmental and host factors influence fungal diversity, with interkingdom interactions affecting fungal colonization.

microRNA profile of endometrial cancer from Indian patients-Identification of potential biomarkers for prognosis

This study profiles microRNAs in Indian endometrial cancer patients, identifies 16 miRNA-mRNA pairs as potential prognostic biomarkers, and compares them to TCGA data.

Chemical-guided SHAPE sequencing (cgSHAPE-seq) informs the binding site of RNA-degrading chimeras targeting SARS-CoV-2 5' untranslated region

The paper develops cgSHAPE-seq to identify RNA-binding sites of coumarin derivatives targeting SARS-CoV-2 5' UTR and demonstrates their use as RNA-degrading chimeras to reduce viral RNA expression.

A dirofilariasis mouse model for heartworm preclinical research

This paper establishes a mouse model for heartworm drug screening, showing it can effectively assess drug efficacy against D. immitis larvae.

Identification and characterization of two CRISPR-Cas systems associated with the mosquito microbiome

The paper identifies and characterizes two CRISPR-Cas systems in a mosquito-associated bacterium, revealing differences in their target sequences and potential roles in defense against plasmids and phages.

Aedes aegypti gut transcriptomes respond differently to microbiome transplants from field-caught or laboratory-reared mosquitoes.

This study compares gut transcriptomic responses of mosquitoes to microbiome transplants from field-caught versus laboratory-reared donors, finding greater gene expression variation with field microbiomes.

Active zone protein SYD-2/Liprin-α acts downstream of LRK-1/LRRK2 to regulate polarized trafficking of synaptic vesicle precursors through clathrin adaptor protein complexes

This study identifies SYD-2/Liprin-α as a downstream effector of LRK-1/LRRK2 that regulates polarized trafficking of synaptic vesicle precursors through AP-3 and AP-1 complexes in C. elegans neurons.

Intratumoral mregDC and CXCL13 T helper niches enable local differentiation of CD8 T cells following PD-1 blockade

The paper identifies intratumoral niches involving mregDC and CXCL13+ Th cells that support CD8 T cell differentiation following PD-1 blockade in HCC patients.

Vertical and horizontal transmission of cell fusing agent virus in Aedes aegypti

This study investigates the transmission routes of CFAV in Aedes aegypti, finding vertical and paternal transmission rates and suggesting strategies for arbovirus control.

Reward quantity discrimination in an associative learning task in wild zebrafish (Danio rerio)

This study tests reward quantity discrimination in wild zebrafish using an operant conditioning task and finds some fish can discriminate between stimuli associated with different rewards.

Inter-species microbiota transplantation recapitulates microbial acquisition and persistence in mosquitoes

This study successfully transfers microbial communities between mosquito species and within species, demonstrating microbiome transplantation in mosquitoes and its impact on microbiota dynamics.

Systemic inflammation recruits fast-acting anti-inflammatory innate myeloid progenitors from BM into lymphatics

The paper shows that systemic inflammation triggers rapid migration of specific myeloid progenitors from bone marrow to lymphatics via Ccl19/Ccr7, promoting anti-inflammatory responses and replenishment of lymph node dendritic cells.

Mayaro Virus Infection Elicits an Innate Immune Response in Anopheles stephensi

This study examines the transcriptomic and small RNA responses of Anopheles stephensi to Mayaro virus infection, identifying regulated genes, novel miRNAs, and an siRNA response targeting the virus.

Genomic and microscopic evidence of stable high density and maternally inherited Wolbachia infections in Anopheles mosquitoes

The paper identifies high-density, maternally inherited Wolbachia infections in Anopheles mosquitoes using genomic and microscopic evidence, suggesting their potential for biocontrol.

Microbial interactions in the mosquito gut determine Serratia colonization and blood feeding propensity.

This study investigates how microbial interactions in the mosquito gut affect Serratia colonization and blood feeding behavior in Ae. aegypti.

Gut-associated bacteria invade the midgut epithelium of Aedes aegypti and stimulate innate immunity and suppress Zika virus infection in cells.

This study shows gut bacteria invade mosquito cells, activate immune pathways, and reduce Zika virus infection.

Dynamic clustering regulates activity of mechanosensitive membrane channels

The paper develops a model showing that mechanosensitive channels cluster under stress, leading to inactivation and protecting the cell from cytoplasmic loss.

CRISPR/Cas9-mediated gene deletion of the ompA gene in an Enterobacter gut symbiont impairs biofilm formation and reduces gut colonization of Aedes aegypti mosquitoes

This study uses CRISPR/Cas9 to delete the ompA gene in an Enterobacter gut symbiont of Aedes aegypti, showing impaired biofilm formation and reduced gut colonization in adults.

Novel Wolbachia strains in Anopheles malaria vectors from Sub-Saharan Africa

The paper identifies novel Wolbachia strains in multiple Anopheles species from Sub-Saharan Africa and assesses their association with Plasmodium infection.

Microbiome interaction networks and community structure from lab-reared and field-collected Aedes aegypti, Aedes albopictus, and Culex quinquefasciatus mosquito vectors.

The paper analyzes microbiome interactions in mosquitoes to identify co-occurrence and co-exclusion patterns across species and environments.

Global transcriptome analysis of Aedes aegypti mosquitoes in response to Zika virus infection

This study analyzes the transcriptome of Aedes aegypti mosquitoes infected with Zika virus at 2, 7, and 14 days post-infection, identifying changes in transcripts and long intergenic non-coding RNAs.