Non-canonical open reading frames encode functional proteins essential for cancer cell survival
J. R. Prensner, O. M. Enache, V. Luria, K. Krug, K. R. Clauser, J. M. Dempster, A. Karger, L. Wang, K. Stumbraite, V. M. Wang, G. Botta, N. J. Lyons, A. Goodale, Z. Kalani, B. Fritchman, , T. R. Golub
The paper identifies non-canonical open reading frames (ORFs) that encode functional proteins essential for cancer cell survival, with one example, GREP1, showing preferential essentiality in breast cancer.
bioRxiv · Mar 10, 2020 · PreprintCancer Biology