Author

A. Karger

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 2 Microbiology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 4 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Organism:chicken / avian· 1

Frequent Co-Authors

T. C. Mettenleiter· 2 shared V. Luria· 2 shared A. Breithaupt· 1 shared A. Brown· 1 shared A. Goodale· 1 shared A. H. O'Donnell-Luria· 1 shared A. Kimoto· 1 shared B. Fritchman· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersMicrobiology

T. C. Mettenleiter

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Author profile →

5 papers

Recent·Most cited

Functional associations of evolutionarily recent human genes exhibit sensitivity to the 3D genome landscape and disease

K. Fleck, V. Luria, N. Garag, A. Karger, T. Hunter, D. Marten, W. Phu, K.-M. Nam, N. Sestan, A. H. O'Donnell-Luria, J. Erceg

The paper examines how the 3D genome landscape and disease influence the functional associations of human genes based on their evolutionary age and lineage restriction.

bioRxiv · Mar 17, 2024 · PreprintEvolutionary Biology

CP204L Is a Multifunctional Protein of African Swine Fever Virus That Interacts with The VPS39 Subunit of HOPS Complex and Promotes Lysosome Clustering

K. M. Dolata, W. Fuchs, G. Caignard, J. Dupre, K. Pannhorst, S. Blome, T. C. Mettenleiter, A. Karger

This study identifies CP204L as an ASFV protein that interacts with VPS39, altering lysosome dynamics and promoting virus replication.

bioRxiv · Sep 9, 2022Microbiology

Preferential selection and contribution of non-structural protein 1 (NS1) to the efficient transmission of the panzootic avian influenza H5N8 2.3.4.4 clades A and B viruses in chickens and ducks

C. Blaurock, A. Breithaupt, D. Scheibner, O. Bagato, A. Karger, T. C. Mettenleiter, E. M. Abdelwhab

This study identifies NS1 protein length variations in H5N8 avian influenza viruses that affect their transmission and virulence in chickens and ducks.

bioRxiv · Mar 14, 2021Microbiology

Non-canonical open reading frames encode functional proteins essential for cancer cell survival

J. R. Prensner, O. M. Enache, V. Luria, K. Krug, K. R. Clauser, J. M. Dempster, A. Karger, L. Wang, K. Stumbraite, V. M. Wang, G. Botta, N. J. Lyons, A. Goodale, Z. Kalani, B. Fritchman, , T. R. Golub

The paper identifies non-canonical open reading frames (ORFs) that encode functional proteins essential for cancer cell survival, with one example, GREP1, showing preferential essentiality in breast cancer.

bioRxiv · Mar 10, 2020 · PreprintCancer Biology

The first functional characterization of ancient interleukin-15-like (IL-15L) reveals shared and distinct functions of the IL-2, -15 and -15L family cytokines

T. Yamaguchi, A. Karger, M. Keller, E. Wangkahart, T. Wang, C. J. Secombes, A. Kimoto, M. Furihata, K. Hashimoto, U. Fischer, J. M. Dijkstra

This study characterizes the functional roles of IL-15L in rainbow trout, revealing shared and distinct functions compared to IL-2 and IL-15, and provides insights into cytokine family evolution.

bioRxiv · May 30, 2019 · PreprintEvolutionary Biology