In vivo targeted and deterministic single cell malignant transformation
P. Scerbo, B. Tisserand, M. Delagrange, H. Debare, D. Bensimon, B. Ducos
The paper demonstrates deterministic malignant transformation of a single zebrafish brain cell by optogenetically activating an oncogene and a reprogramming factor, supporting the ground state theory of cancer initiation.
bioRxiv · Jan 30, 2024Cancer Biology