Author

C. BELOIN

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 13 Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 13 Organism:E. coli· 8 Research Focus:host-pathogen & immune response· 6 Organism:bacteria (other)· 3 Research Focus:cell type annotation· 3 Assay:proteomics· 3 Approach:statistical model· 3 Assay:fluorescence / live-cell microscopy· 2

Frequent Co-Authors

J.-M. GHIGO· 14 shared S. Gribaldo· 4 shared J. Witwinowski· 3 shared N. Taib· 3 shared S. LETOFFE· 3 shared N. Bechon· 2 shared N. Desprat· 2 shared S. Thiriet-Rupert· 2 shared

Activity by Year

2017-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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14 shared papersMicrobiology

J.-M. GHIGO

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Author profile →

15 papers

Recent·Most cited

An ancestral dual function of OmpM as outer membrane tether and nutrient uptake channel in diderm Firmicutes

A. Silale, Y. Zhu, J. Witwinowski, R. E. Smith, K. E. Newman, S. P. Bhamidimarri, A. Basle, S. Khalid, C. BELOIN, S. Gribaldo, B. van den Berg

This study identifies OmpM as a dual-function protein in diderm Firmicutes that tethers the outer membrane to peptidoglycan and facilitates nutrient uptake.

bioRxiv · Aug 14, 2023Biochemistry

Bridges instead of boats? The Mla system of diderm Firmicute Veillonella parvula reveals an ancestral transenvelope core of phospholipid trafficking

C. BELOIN, K. P. Grasekamp, B. Beaud, N. Taib, B. Audrain, B. Bardiaux, Y. Rossez, N. IZADI-PRUNEYRE, M. Lejeune, X. Trivelli, Z. Chouit, Y. Guerardel, J.-M. GHIGO, S. Gribaldo

This study investigates GPL trafficking in Veillonella parvula, revealing a minimal Mla system that directly connects membranes without chaperones or outer membrane lipoproteins, suggesting an ancestral core of the Mla system.

bioRxiv · Jun 30, 2023 · PreprintMicrobiology

Analysis of in-patient evolution of Escherichia coli reveals potential links to relapse of bone and joint infections

S. Thiriet Rupert, J. Josse, D. Perez Pascual, J. Tasse, C. Andre, L. Abad, D. Lebeaux, J.-M. Ghigo, F. Laurent, C. Beloin

The paper analyzes in-patient evolution of Escherichia coli in bone and joint infections and identifies genetic and phenotypic changes associated with relapse.

bioRxiv · May 10, 2023 · PreprintMicrobiology

Escherichia coli aggregates mediated by native or synthetic adhesins exhibit both core and adhesin-specific transcriptional responses

Y. Chekli, R. J. Stevick, E. Kornobis, V. Briolat, J.-M. Ghigo, C. BELOIN

This study examines transcriptomic responses of E. coli aggregates formed by native or synthetic adhesins, revealing core and adhesin-specific gene expression changes.

bioRxiv · Feb 14, 2023 · PreprintMicrobiology

Escherichia coli SPFH membrane microdomain proteins HflKC contribute to aminoglycoside and oxidative stress tolerance

A. K. Wessel, Y. Yoshii, A. Reder, R. Boudjemaa, M. Szczesna, J.-M. Betton, J. Bernal-Bayard, C. Beloin, D. Lopez, U. Volker, J.-M. Ghigo

This study shows that HflKC in E. coli contributes to tolerance of aminoglycosides and oxidative stress, and their localization depends on cardiolipin biosynthesis.

bioRxiv · Jul 25, 2022 · PreprintMicrobiology

Bacterial capsular polysaccharides with antibiofilm activity share common biophysical and electrokinetic properties

J. BAYARD-BERNAL, J. THIEBAUD, M. BROSSAUD, A. BEAUSSART, C. CAILLET, Y. WALDVOGEL, L. TRAVIER, S. LETOFFE, T. FONTAINE, B. ROKBI, P. TALAGA, C. BELOIN, N. MISTRETTA, J. F. L. DUVAL, J.-M. GHIGO

This study identifies nine capsular polysaccharides with antibiofilm activity and shows they share common electrokinetic and biophysical properties distinguishing them from inactive polymers.

bioRxiv · May 27, 2022 · PreprintMicrobiology

Intermittent antibiotic treatment of bacterial biofilms favors the rapid evolution of resistance

M. Usui, Y. Yoshii, S. Thiriet-Rupert, J.-M. Ghigo, C. BELOIN

This study shows that intermittent antibiotic treatment of bacterial biofilms leads to rapid evolution of resistance mutations, which are not observed in planktonic populations.

bioRxiv · May 3, 2022 · PreprintMicrobiology

Volatile hydrogen cyanide released by Pseudomonas aeruginosa provides a competitive advantage over Staphylococcus aureus in biofilm and in vivo lung environments

S. Letoffe, Y. Wu, S. E. Darch, C. Beloin, M. Whiteley, L. Touqui, J.-M. Ghigo

This study shows that Pseudomonas aeruginosa releases volatile hydrogen cyanide (HCN) that inhibits Staphylococcus aureus growth in low oxygen environments, providing a competitive advantage in biofilms and in vivo lung infections.

bioRxiv · Mar 24, 2022 · PreprintMicrobiology

Selection for non-specific adhesion is a driver of FimH evolution increasing Escherichia coli biofilm capacity

M. YOSHIDA, S. THIRIET-RUPERT, L. MAYER, C. BELOIN, J.-M. GHIGO

This study shows that mutations in FimH enhance E. coli's non-specific adhesion to surfaces, increasing biofilm formation despite reduced specific mannose binding.

bioRxiv · Aug 3, 2021Microbiology

An ancient divide in outer membrane tethering systems in Bacteria

J. Witwinowski, A. Sartori-Rupp, N. Taib, N. Pende, T. N. Tham, D. Poppleton, J.-M. Ghigo, C. Beloin, S. Gribaldo

The paper investigates the evolution of outer membrane tethering systems in bacteria, showing a bimodal distribution linked to phylogeny and proposing a mechanism for the loss of the outer membrane in Gram-positive bacteria.

bioRxiv · May 31, 2021 · PreprintMicrobiology

Lifestyle-specific S-nitrosylation of protein cysteine thiols regulates Escherichia coli biofilm formation and resistance to oxidative stress

N. BARRAUD, S. LETOFFE, C. BELOIN, J. VINH, G. CHIAPPETTA, J.-M. GHIGO

This study identifies biofilm-specific S-nitrosylation in E. coli that affects redox homeostasis and oxidative stress resistance.

bioRxiv · Sep 29, 2020Microbiology

Visualizing the dynamics of exported bacterial proteins with the chemogenetic fluorescent reporter FAST

Y. Chekli, C. Peron-Cane, D. Dell'Arciprete, J.-F. Allemand, C. Li, J.-M. GHIGO, A. Gautier, A. Lebreton, N. Desprat, C. BELOIN

This study uses FAST, a chemogenetic fluorescent reporter, to visualize exported bacterial proteins in live imaging, demonstrating its functionality on both diderm and monoderm bacteria.

bioRxiv · May 12, 2020Microbiology

Autotransporters drive biofilm formation and auto-aggregation in the diderm Firmicute Veillonella parvula

N. Bechon, A. Jimenez-Fernandez, J. Witwinowski, E. Bierque, N. Taib, T. Cokelaer, L. Ma, J.-M. Ghigo, S. Gribaldo, C. Beloin

This study identifies autotransporters as key drivers of biofilm formation and auto-aggregation in Veillonella parvula using genetic tools and functional analyses.

bioRxiv · Apr 15, 2020Microbiology

Capsular polysaccharides cross-regulation modulates Bacteroides thetaiotaomicron biofilm formation

N. BECHON, J. MIHAJLOVIC, S. VENDRELL-FERNANDEZ, F. CHAIN, P. LANGELLA, C. BELOIN, J.-M. GHIGO

This study identifies capsular polysaccharide cross-regulation as a key determinant of Bacteroides thetaiotaomicron biofilm formation, showing that capsule 8 has intrinsic adhesive properties while other capsules inhibit biofilm formation.

bioRxiv · Mar 25, 2020Microbiology

Asymmetric adhesion of rod-shaped bacteria controls microcolony morphogenesis

M.-C. Duvernoy, T. Mora, M. Ardre, V. Croquette, D. Bensimon, C. Quilliet, J.-M. Ghigo, M. Balland, C. Beloin, S. Lecuyer, N. Desprat

This study shows asymmetric adhesion in rod-shaped bacteria drives microcolony shape and signal circulation during biofilm formation.

bioRxiv · Jan 31, 2017Biophysics