J.-M. GHIGO

Bile-induced biofilm formation in Bacteroides thetaiotaomicron requires magnesium efflux by an RND pump

This paper identifies a bile-induced RND efflux pump in Bacteroides thetaiotaomicron that facilitates magnesium efflux, reducing eDNA concentration and promoting biofilm formation.

Bridges instead of boats? The Mla system of diderm Firmicute Veillonella parvula reveals an ancestral transenvelope core of phospholipid trafficking

This study investigates GPL trafficking in Veillonella parvula, revealing a minimal Mla system that directly connects membranes without chaperones or outer membrane lipoproteins, suggesting an ancestral core of the Mla system.

Analysis of in-patient evolution of Escherichia coli reveals potential links to relapse of bone and joint infections

The paper analyzes in-patient evolution of Escherichia coli in bone and joint infections and identifies genetic and phenotypic changes associated with relapse.

Anti-diarrheal drug loperamide induces dysbiosis in zebrafish microbiota via bacterial inhibition

This paper shows loperamide induces dysbiosis in zebrafish microbiota by directly inhibiting bacterial growth.

Escherichia coli aggregates mediated by native or synthetic adhesins exhibit both core and adhesin-specific transcriptional responses

This study examines transcriptomic responses of E. coli aggregates formed by native or synthetic adhesins, revealing core and adhesin-specific gene expression changes.

Gnotobiotic zebrafish microbiota display inter-individual variability affecting host physiology

This study shows inter-individual variability in gnotobiotic zebrafish microbiota colonization affecting host mucus production and experimental reproducibility.

Escherichia coli SPFH membrane microdomain proteins HflKC contribute to aminoglycoside and oxidative stress tolerance

This study shows that HflKC in E. coli contributes to tolerance of aminoglycosides and oxidative stress, and their localization depends on cardiolipin biosynthesis.

Bacterial capsular polysaccharides with antibiofilm activity share common biophysical and electrokinetic properties

This study identifies nine capsular polysaccharides with antibiofilm activity and shows they share common electrokinetic and biophysical properties distinguishing them from inactive polymers.

Chromosomal position of ribosomal protein genes impacts long term evolution of Vibrio cholerae.

This study shows that the chromosomal position of ribosomal protein genes in V. cholerae affects long-term evolutionary trajectories of growth rate and fitness.

Intermittent antibiotic treatment of bacterial biofilms favors the rapid evolution of resistance

This study shows that intermittent antibiotic treatment of bacterial biofilms leads to rapid evolution of resistance mutations, which are not observed in planktonic populations.

Volatile hydrogen cyanide released by Pseudomonas aeruginosa provides a competitive advantage over Staphylococcus aureus in biofilm and in vivo lung environments

This study shows that Pseudomonas aeruginosa releases volatile hydrogen cyanide (HCN) that inhibits Staphylococcus aureus growth in low oxygen environments, providing a competitive advantage in biofilms and in vivo lung infections.

Selection for non-specific adhesion is a driver of FimH evolution increasing Escherichia coli biofilm capacity

This study shows that mutations in FimH enhance E. coli's non-specific adhesion to surfaces, increasing biofilm formation despite reduced specific mannose binding.

Bacteroides thetaiotaomicron uses a widespread extracellular DNase to promote bile-dependent biofilm formation

This study identifies bile as a trigger for biofilm formation in Bacteroides thetaiotaomicron and shows that extracellular DNA degradation by DNase BT3563 is essential for this process.

An ancient divide in outer membrane tethering systems in Bacteria

The paper investigates the evolution of outer membrane tethering systems in bacteria, showing a bimodal distribution linked to phylogeny and proposing a mechanism for the loss of the outer membrane in Gram-positive bacteria.

Lifestyle-specific S-nitrosylation of protein cysteine thiols regulates Escherichia coli biofilm formation and resistance to oxidative stress

This study identifies biofilm-specific S-nitrosylation in E. coli that affects redox homeostasis and oxidative stress resistance.

Gnotobiotic rainbow trout (Oncorhynchus mykiss) model reveals endogenous bacteria that protect against Flavobacterium columnare infection

Visualizing the dynamics of exported bacterial proteins with the chemogenetic fluorescent reporter FAST

This study uses FAST, a chemogenetic fluorescent reporter, to visualize exported bacterial proteins in live imaging, demonstrating its functionality on both diderm and monoderm bacteria.

Mining zebrafish microbiota reveals key community-level resistance against fish pathogen infection

The paper identifies key bacteria and community-level strategies that confer resistance to fish pathogen infection in zebrafish.

Autotransporters drive biofilm formation and auto-aggregation in the diderm Firmicute Veillonella parvula

This study identifies autotransporters as key drivers of biofilm formation and auto-aggregation in Veillonella parvula using genetic tools and functional analyses.

Capsular polysaccharides cross-regulation modulates Bacteroides thetaiotaomicron biofilm formation

This study identifies capsular polysaccharide cross-regulation as a key determinant of Bacteroides thetaiotaomicron biofilm formation, showing that capsule 8 has intrinsic adhesive properties while other capsules inhibit biofilm formation.

Asymmetric adhesion of rod-shaped bacteria controls microcolony morphogenesis

This study shows asymmetric adhesion in rod-shaped bacteria drives microcolony shape and signal circulation during biofilm formation.