Mechanical Resistance to Micro-Heart Tissue Contractility unveils early Structural and Functional Pathology in iPSC Models of Hypertrophic Cardiomyopathy
J. GUO, H. Jiang, D. Schuftan, J. D. Moreno, G. Ramahdita, L. Aryan, D. Bhagavan, J. Silva, N. Huebsch
This study uses iPSC-derived heart tissue models to show that mechanical stress exacerbates HCM-linked MYBPC3 mutations, leading to structural and functional cardiac pathology.
bioRxiv · Oct 30, 2023 · PreprintBioengineering