UCHL1-dependent control of Hypoxia-Inducible Factor Transcriptional Activity in Liver Disease.
A. Collins, R. Scott, C. L. Wilson, G. Abbate, G. B. Ecclestone, D. Biddles, F. Oakley, J. Mann, D. A. Mann, N. S. Kenneth
This study shows that UCHL1 regulates HIF1 activity in liver fibrosis by cleaving ubiquitin chains, increasing HIF1 levels, and promoting fibrosis.
bioRxiv · Jan 8, 2023 · PreprintCell Biology