Author

G. B. Ecclestone

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Organism:yeast· 1

Frequent Co-Authors

N. S. Kenneth· 2 shared A. Collins· 1 shared C. L. Wilson· 1 shared C. MacDonald· 1 shared D. A. Mann· 1 shared D. Biddles· 1 shared F. Child· 1 shared F. Oakley· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersCell Biology

N. S. Kenneth

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

UCHL1-dependent control of Hypoxia-Inducible Factor Transcriptional Activity in Liver Disease.

A. Collins, R. Scott, C. L. Wilson, G. Abbate, G. B. Ecclestone, D. Biddles, F. Oakley, J. Mann, D. A. Mann, N. S. Kenneth

This study shows that UCHL1 regulates HIF1 activity in liver fibrosis by cleaving ubiquitin chains, increasing HIF1 levels, and promoting fibrosis.

bioRxiv · Jan 8, 2023 · PreprintCell Biology

Disruption of HIF1A translational control attenuates the HIF-dependent hypoxic response and solid tumour formation in vivo

J. E. Hunter, O. McHugh, G. B. Ecclestone, F. Child, H. Mearns, G. Robson, M. Dadzie, S. Rocha, N. D. Perkins, N. S. Kenneth

This study shows that disrupting HIF1A translational control reduces hypoxic response and solid tumour formation in mice.

bioRxiv · Nov 2, 2022 · PreprintCancer Biology

Fur4 mediated uracil-scavenging to screen for surface protein regulators

K. M. Paine, G. B. Ecclestone, C. MacDonald

The paper develops a yeast-based assay to screen for surface protein regulators by measuring uracil-scavenging activity and identifies factors involved in membrane trafficking and transcriptional control.

bioRxiv · May 27, 2021Cell Biology