Author

J. Mann

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Ecology· 2 Animal Behavior & Cognition· 1 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:bacteria (other)· 3 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Research Focus:drug response / drug discovery· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

F. Oakley· 3 shared A.-M. Jacoby· 2 shared D. A. Mann· 2 shared E. M. Patterson· 2 shared H. Paish· 2 shared J. Leslie· 2 shared L. Borthwick· 2 shared M. A. Collier· 2 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersCell Biology

F. Oakley

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Automated Skin Lesion Detection and Prevalence Estimation in Tamanend's Bottlenose Dolphins

C. J. Murphy, M. A. Collier, A.-M. Jacoby, E. M. Patterson, M. M. Wallen, J. Mann, S. Bansal

This paper develops a machine learning model to detect skin lesions in bottlenose dolphins and estimates lesion prevalence, finding high model accuracy and a positive relationship between lesion presence and gregariousness.

bioRxiv · Jul 15, 2024Ecology

Breathing in sync: how a social behavior structures respiratory epidemic risk in bottlenose dolphins

M. A. Collier, A.-M. Jacoby, V. Foroughirad, E. M. Patterson, E. Krzyszczyk, M. M. Wallen, M. Miketa, C. Karniski, S. Wilkin, J. Mann, S. Bansal

This study examines how social breathing behavior in bottlenose dolphins influences respiratory virus transmission risk by analyzing contact patterns and demographic differences.

bioRxiv · Dec 1, 2023Ecology

Antibodies generated in vitro and in vivo elucidate design of a thermostable ADDomer COVID-19 nasal nanoparticle vaccine

D. Buzas, H. A. Bunzel, O. Staufer, E. Milodowski, G. Edmonds, J. Bufton, B. Vidana Matteo, S. Yadav, K. Gupta, C. Fletcher, M. Kavanagh Williamson, A. Harrison, U. Borucu, J. Capin, O. Francis, , I. Berger

This study develops a thermostable ADDomer-based nanoparticle vaccine that neutralizes SARS-CoV-2 and cross-reacts with VOCs, demonstrating its potential for nasal administration.

bioRxiv · Mar 17, 2023Biochemistry

UCHL1-dependent control of Hypoxia-Inducible Factor Transcriptional Activity in Liver Disease.

A. Collins, R. Scott, C. L. Wilson, G. Abbate, G. B. Ecclestone, D. Biddles, F. Oakley, J. Mann, D. A. Mann, N. S. Kenneth

This study shows that UCHL1 regulates HIF1 activity in liver fibrosis by cleaving ubiquitin chains, increasing HIF1 levels, and promoting fibrosis.

bioRxiv · Jan 8, 2023 · PreprintCell Biology

Changes in Social Position Predict Survival in Bottlenose Dolphins

R. W. Rankin, V. J. Foroughirad, E. B. Krzyszczyk, C. H. Frere, J. Mann

This study shows that changes in social network position, not the number or strength of bonds, predict survival in bottlenose dolphins, mirroring the human widowhood effect.

bioRxiv · Aug 25, 2022 · PreprintAnimal Behavior & Cognition

mTORC1-Plin3 pathway is essential to activate lipophagy and protects against hepatosteatosis.

M. Garcia-Macia, A. Santos-Ledo, J. Leslie, H. Paish, A. Watson, L. Borthwick, J. Mann, F. Oakley, V. I. Korolchuk, D. A. Mann

This study identifies the mTORC1-Plin3 pathway as essential for lipophagy, which protects against hepatosteatosis by promoting lipid droplet degradation.

bioRxiv · Oct 21, 2019Cell Biology

Length-independent telomere damage drives cardiomyocyte senescence

R. Anderson, A. Lagnado, D. Maggiorani, A. Walaszczyk, E. Dookun, J. Chapman, J. Birch, H. Salmonowicz, M. Ogrodnik, D. Jurk, C. Proctor, C. Correia-Melo, S. Victorelli, E. Fielder, R. Berlinguer-Palmini, , J. F. Passos

This study shows that telomere damage independent of length causes cardiomyocyte senescence, leading to cardiac dysfunction, and that clearing senescent cells improves cardiac health.

bioRxiv · Aug 17, 2018Cell Biology

A novel bioreactor technology for modelling fibrosis in human and rodent precision-cut liver slices.

H. Paish, L. Reed, H. Brown, M. Bryan, O. Govaere, J. Leslie, B. Barksby, J. French, S. White, D. Manas, S. Robinson, G. Spoletini, C. Griffiths, D. Mann, L. Borthwick, , F. Oakley

This paper develops a bioreactor system that extends the viability of precision-cut liver slices (PCLS) to 6 days under normoxic conditions and demonstrates its use in modeling fibrogenesis and testing anti-fibrotic drugs.

bioRxiv · May 25, 2018Cell Biology