Single-cell multi-omics analyses reveal EZH2 as a main driver of retinoic acid resistance in PLZF-RARA leukemia.
M. Poplineau, N. Platet, A. Mazuel, L. Herault, S. Koide, W. Kuribayashi, N. Carbuccia, L. N'Guyen, J. Vernerey, M. Oshima, D. Birnbaum, A. Iwama, E. Duprez
This study identifies EZH2 as a driver of retinoic acid resistance in PLZF-RARA leukemia using single-cell multi-omics analyses and shows targeting pan-EZH2 activities can eliminate resistant cells.
bioRxiv · Jan 4, 2022 · PreprintCancer Biology