S. Audebert

Downregulation of stromal syntenin sustains AML development

This study shows that reduced stromal syntenin in bone marrow stromal cells promotes AML aggressiveness by enhancing AML cell survival and protein synthesis through endoglin upregulation.

Integrative study of skeletal muscle mitochondrial dysfunction in a murine pancreatic cancer-induced cachexia model

This study investigates mitochondrial dysfunction in skeletal muscle of a murine pancreatic cancer-induced cachexia model, identifying metabolic defects beyond traditional pathways.

The serine/threonine kinase MINK1 directly regulates the function of promigratory proteins

This study identifies MINK1 as a kinase that phosphorylates LL5β, a component of the PRICKLE1 complex, promoting cell migration in triple-negative breast cancer and associating with poor metastasis-free survival.

Insights into animal septins using recombinant human septin octamers with distinct SEPT9 isoforms

This study isolates recombinant human septin octamers with distinct SEPT9 isoforms and shows they form filament assemblies and bind actin filaments.

PLD2-phosphatidic acid recruit ESCRT-I to late endosomes for exosome biogenesis.

The paper shows PLD2 and phosphatidic acid recruit ESCRT-I to late endosomes, facilitating exosome biogenesis through MVB12B interactions.

A novel Golgi-associated Vangl2 translational variant required for PCP regulation in vertebrates

The paper identifies a novel Vangl2 isoform, Vangl2-Long, which is localized to the Golgi apparatus and plays a critical role in PCP regulation in vertebrates.

E-cadherin is a structuring component of invadopodia in pancreatic cancer

This study identifies E-cadherin as a critical structural component of invadopodia in pancreatic cancer cells, showing its role in invadopodia formation and structuration through interactions with Arp2/3, Cortactin, and MT1-MMP.

Biophysical forces rewire cell metabolism to guide microtubule-dependent cell mechanics

This study shows mechanical forces rewire glutamine metabolism to promote microtubule glutamylation, affecting cell mechanics and mechanodependent functions.

iASPP contributes to cortex rigidity, astral microtubule capture and mitotic spindle positioning

This study shows iASPP interacts with EB1 and Myo1c to regulate cortical rigidity, microtubule capture, and spindle positioning during mitosis.

A proximity-labeling proteomic approach to investigate invadopodia molecular landscape in breast cancer cells

The paper develops a proteomic approach using BioID to identify invadopodia components in breast cancer cells, revealing novel Tks5 partners and their role in actin cytoskeleton organization.

Targeting DDR1 and DDR2 overcomes matrix-mediated melanoma cell adaptation to BRAF-targeted therapy

This study shows that targeting DDR1 and DDR2 overcomes matrix-mediated resistance to BRAF inhibitors in melanoma by disrupting ECM-driven survival pathways.

CRB2 controls primary ciliogenesis in association with PAR6α, HOOK2 and RAB8A

This study shows CRB2 is required for primary ciliogenesis by forming a complex with HOOK2 and PAR6 and interacting with RAB8A to regulate membrane transport for ciliary vesicle formation.

ECT2 associated to PRICKLE1 are poor-prognosis markers in triple-negative breast cancer

The paper identifies PRICKLE1 and ECT2 as poor-prognosis markers in triple-negative breast cancer by showing their interaction and role in RAC1 signaling.