M. Oshima

Tumor-microvessel on-a-chip reveals sequential intravasation cascade of cancer cell clusters

This study develops a 3D in vitro system to visualize tumor intravasation of CTC clusters and identifies TGF-β and activin signaling as essential for this process.

Spatiotemporal observation reveals metastatic tumor-driven vascular remodeling as a potential route to polyclonal colonization

The paper investigates extravasation mechanisms in metastatic tumors using a 3D microvessel model and time-lapse imaging, revealing vascular remodeling as a key process in polyclonal colonization.

Development of a 3D vascular network visualization platform for one-dimensional hemodynamic simulation

This paper develops a 3D vascular network visualization platform for 1D-0D hemodynamic simulations, demonstrating its use in surgical planning and complication prevention.

Interferon-α promotes neo-antigen formation andpreferential HLA-B-restricted antigen presentation in pancreatic β-cells

This study shows that IFN-α increases HLA-B-restricted antigen presentation in pancreatic β-cells, potentially influencing T1D pathogenesis.

qMaLioffG: A single green fluorescent protein FLIM indicator enabling quantitative imaging of endogenous ATP

The paper introduces qMaLioffG, a green fluorescent protein FLIM indicator that quantitatively measures endogenous ATP levels by detecting fluorescence lifetime changes in physiological ATP concentrations.

Context-Dependent Modification of PFKFB3 in Hematopoietic Stem Cells Promotes Anaerobic Glycolysis and Ensures Stress Hematopoiesis

This study identifies PFKFB3 as a key regulator of glycolytic metabolism in HSCs under stress, showing its context-dependent activation promotes ATP production and hematopoiesis.

High-resolution glucose tracing and in situ imaging reveals regulated lactate production in human pancreatic β cells

The paper uses metabolic tracing and imaging to show that human pancreatic β cells produce lactate, regulated by LDHB expression, which affects Ca2+ spiking without altering ATP/ADP levels.

Polycomb repressive complex 1.1 coordinates homeostatic and emergency myelopoiesis

This study identifies PRC1.1 as a regulator of homeostatic and emergency myelopoiesis, showing its role in balancing myeloid differentiation and preventing transformation.

Uncertainty quantification in cerebral circulation simulations focusing on the collateral flow: Surrogate model approach with machine learning

This paper develops a machine learning surrogate model to rapidly quantify uncertainty in cerebral circulation simulations, enabling real-time risk assessment of cerebral hyperperfusion after carotid artery stenosis surgery.

Single-cell multi-omics analyses reveal EZH2 as a main driver of retinoic acid resistance in PLZF-RARA leukemia.

This study identifies EZH2 as a driver of retinoic acid resistance in PLZF-RARA leukemia using single-cell multi-omics analyses and shows targeting pan-EZH2 activities can eliminate resistant cells.

The kinesin KIF4 mediates HBV/HDV entry through regulation of surface NTCP localization and can be targeted by RXR agonists in vitro.

This paper identifies KIF4 as a critical regulator of NTCP surface localization for HBV/HDV entry and shows RXR agonists can suppress KIF4 to inhibit viral infection.

Catalytic Promiscuity of Rice 2-Oxoglutarate/Fe(II)-Dependent Dioxygenases Supports Xenobiotic Metabolism

The study shows that rice HIS1 and related enzymes can metabolize both herbicides and the plant growth regulator trinexapac-ethyl, demonstrating catalytic promiscuity in xenobiotic metabolism.

Adaptive fitness in APC-mutant cells requires chromosome rearrangements

The paper shows that APC-mutant cells gain adaptive fitness through chromosome rearrangements that restore AURKA activity and counteract mitotic defects.

Genome-Scale CRISPR Screening reveals novel factors regulating Wnt-dependent regeneration of mouse gastric organoids

The paper uses CRISPR screening to identify novel factors regulating Wnt-dependent regeneration of mouse gastric organoids, finding that Alk, Bclaf3, and Prkra suppress Wnt-driven self-renewal.