Shigella ipaA mediates actin bundling through diffusible vinculin oligomers with activation imprint
C. M. Valencia-Gallardo, D. I. Aguilar, H. Khakzad, B. Cocom-Chan, C. Bou-Nader, C. Velours, Y. Zarrouk, C. Le Clainche, C. Malosse, D. Borges-Lima, N. Quenech'Du, B. Mazhar, S. Essid, M. Fontecave, A. Asnacios, , G. Tran Van Nhieu
This study shows that Shigella IpaA induces vinculin homo-oligomerization, leading to actin bundling and stable cell adhesion independent of force transduction.
bioRxiv · Nov 7, 2022 · PreprintMicrobiology