Functional and structural insights into the multi-step activation and catalytic mechanism of bacterial ExoY nucleotidyl cyclase toxins bound to actin-profilin
M. Teixeira-Nunes, P. Retailleau, D. Raoux-Barbot, M. Comisso, A. A. Missinou, C. Velours, S. Plancqueel, D. Ladant, U. Mechold, L. Renault
This paper investigates the activation and catalytic mechanism of ExoY toxins by analyzing their interaction with actin and profilin, revealing structural insights into their multi-step activation process.
bioRxiv · Jan 13, 2023 · PreprintBiochemistry