H. Khakzad

This study shows that increasing Fc flexibility in an IgG1-IgG3 hybrid monoclonal antibody enhances opsonic function and protection against group A streptococci.

This study shows IpaA activates vinculin in distinct ways during Shigella invasion and cell-matrix adhesion, with different effects on invasion and adhesion.

This study shows that Shigella IpaA induces vinculin homo-oligomerization, leading to actin bundling and stable cell adhesion independent of force transduction.

This study examines opsonic antibody responses to invasive S. pyogenes infections, finding modest increases in antibody binding and variable opsonic capacity across strains.

This study shows that non-neutralizing Spike-specific antibodies can enhance phagocytosis of SARS-CoV-2 by monocytes, potentially offering protection despite not neutralizing the virus.

The paper describes a human monoclonal antibody that binds two distinct epitopes on streptococcal M protein via a bivalent dual-Fab cis mode, providing protection against infection.

This study identifies serotype- and microenvironment-dependent protein interactions between Streptococcus pyogenes and host proteins using mass spectrometry and modeling.