RD5-mediated lack of PE_PGRS and PPE-MPTR export in BCG vaccine strains results in strong reduction of antigenic repertoire but little impact on protection
L. S. Ates, F. Sayes, W. Frigui, R. Ummels, M. P. M. Damen, D. Bottai, M. A. Behr, W. Bitter, L. Majlessi, R. Brosch
This study shows that BCG vaccine strains lack PE_PGRS/PPE-MPTR export due to RD5 inactivation, reducing antigenic repertoire but not vaccine efficacy.
bioRxiv · Feb 14, 2018Microbiology