Author

R. Ummels

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:protein folding & dynamics· 3 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

W. Bitter· 4 shared C. M. Bunduc· 2 shared A. Pain· 1 shared Abdallah M. Abdallah· 1 shared D. Bottai· 1 shared D. Fahrenkamp· 1 shared E. N. G. Houben· 1 shared E. N. Houben· 1 shared

Activity by Year

2018-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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4 shared papersMicrobiology

W. Bitter

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4 papers

Recent·Most cited

Structure and dynamics of the ESX-5 type VII secretion system of Mycobacterium tuberculosis

C. M. Bunduc, D. Fahrenkamp, J. Wald, R. Ummels, W. Bitter, E. N. G. Houben, T. C. Marlovits

The paper presents the first structure of the ESX-5 T7SS inner membrane complex in M. tuberculosis, revealing its assembly, stabilization, and potential secretion mechanism.

bioRxiv · Dec 2, 2020Microbiology

Species-specific secretion of ESX-5 type VII substrates is determined by the linker 2 of EccC5

C. M. Bunduc, R. Ummels, W. Bitter, E. N. Houben

The study identifies linker 2 of EccC5 as the determinant for species-specific secretion of ESX-5 substrates in mycobacteria.

bioRxiv · Sep 11, 2019Microbiology

WhiB6 is required for the secretion-dependent regulation of ESX-1 substrates in pathogenic mycobacteria.

Abdallah M. Abdallah, E.M. Weerdenburg, Qingtian Guan, R. Ummels, S. Borggreve, S.A. Adroub, Tareq B. Malas, Raeece Naeem, Huoming Zhang, T.D. Otto, W. Bitter, A. Pain

This study shows that WhiB6 regulates ESX-1 substrate secretion in mycobacteria, independent of structural components, through transcriptional control and protein interactions.

bioRxiv · May 2, 2018 · PreprintMicrobiology

RD5-mediated lack of PE_PGRS and PPE-MPTR export in BCG vaccine strains results in strong reduction of antigenic repertoire but little impact on protection

L. S. Ates, F. Sayes, W. Frigui, R. Ummels, M. P. M. Damen, D. Bottai, M. A. Behr, W. Bitter, L. Majlessi, R. Brosch

This study shows that BCG vaccine strains lack PE_PGRS/PPE-MPTR export due to RD5 inactivation, reducing antigenic repertoire but not vaccine efficacy.

bioRxiv · Feb 14, 2018Microbiology