Author

W. Bitter

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 9 Cell Biology· 1

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Approach:experimental assay· 9 Research Focus:host-pathogen & immune response· 5 Research Focus:cell type annotation· 4 Research Focus:protein folding & dynamics· 4 Research Focus:cell signaling & trafficking· 3 Organism:mouse· 3 Organism:bacteria (other)· 2 Assay:bulk RNA-seq· 2

Frequent Co-Authors

R. Ummels· 4 shared C. M. Bunduc· 3 shared E. N. G. Houben· 3 shared M. P. M. Damen· 2 shared R. Brosch· 2 shared T. C. Marlovits· 2 shared A. Domenech· 1 shared A. Garcia-Puente· 1 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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4 shared papersMicrobiology

R. Ummels

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Author profile →

10 papers

Recent·Most cited

The carboxyl-terminal processing proteases Prc and CtpA modulate cell-surface signalling activity and Pseudomonas aeruginosa virulence

J. R. Otero-Asman, A. Sanchez-Jimenez, K. C. Bastiaansen, S. Wettstadt, C. Civantos, A. Garcia-Puente, W. Bitter, M. Llamas

This study identifies CtpA as a protease that modulates CSS activation and virulence in Pseudomonas aeruginosa by regulating the anti-{sigma} factor, with implications for drug development.

bioRxiv · Mar 13, 2023 · PreprintMicrobiology

Reconstitution of a minimal ESX-5 type VII secretion system suggests a role for PPE proteins in outer membrane transport of proteins

C. M. Bunduc, Y. Ding, C. Kuijl, T. C. Marlovits, W. Bitter, E. N. G. Houben

The paper reconstitutes the ESX-5 T7SS in Mycobacterium smegmatis to show that PPE proteins localize to the outer membrane and are required for active secretion.

bioRxiv · Sep 5, 2022Microbiology

The ESX-1 substrate PPE68 has a key function in the ESX-1 mediated secretion in Mycobacterium marinum

M. P. M. Damen, A. S. Meijers, E. M. Keizer, S. R. Piersma, C. Jimenez, C. P. Kuijl, W. Bitter, E. N. G. Houben

This paper identifies PPE68 as essential for ESX-1 mediated secretion of EsxA and EspE in M. marinum, revealing distinct domains of PPE68 involved in different secretion processes.

bioRxiv · Jun 21, 2022Microbiology

Pneumolysin promotes host cell necroptosis and bacterial competence during pneumococcal meningitis as shown by whole animal dual RNA-seq

K. K. Jim, R. Aprianto, A. Domenech, J. Kurushima, D. van de Beek, C. M. J. E. Vandenbroucke-Grauls, W. Bitter, J.-W. Veening

bioRxiv · Feb 10, 2022Microbiology

Structure and dynamics of the ESX-5 type VII secretion system of Mycobacterium tuberculosis

C. M. Bunduc, D. Fahrenkamp, J. Wald, R. Ummels, W. Bitter, E. N. G. Houben, T. C. Marlovits

The paper presents the first structure of the ESX-5 T7SS inner membrane complex in M. tuberculosis, revealing its assembly, stabilization, and potential secretion mechanism.

bioRxiv · Dec 2, 2020Microbiology

IL-1R1 dependent signals improve clearance of cytosolic virulent mycobacteria in vivo

S. van der Niet, M. van Zon, K. de Punder, A. Grootemaat, S. Rutten, S. Moorlag, D. Houben, A. van der Sar, W. Bitter, R. Brosch, R. Hernandez, M. T. Pena, P. J. Peters, E. E. Reits, K. D. Mayer-Barber, N. van der Wel

The paper shows that IL-1R1-dependent signals enhance clearance of cytosolic mycobacteria in vivo, particularly when host immunity is compromised.

bioRxiv · Sep 27, 2020Cell Biology

New flat embedding method for transmission electron microscopy reveals an unknown mechanism of tetracycline

M. Wenzel, M. P. Dekker, B. Wang, M. J. Burggraaf, W. Bitter, J. R. van Weering, L. W. Hamoen

This paper introduces a new flat embedding method for TEM that enables large-scale quantification of bacterial morphological changes, revealing tetracycline's previously unknown membrane-disrupting activity.

bioRxiv · Oct 28, 2019Microbiology

Species-specific secretion of ESX-5 type VII substrates is determined by the linker 2 of EccC5

C. M. Bunduc, R. Ummels, W. Bitter, E. N. Houben

The study identifies linker 2 of EccC5 as the determinant for species-specific secretion of ESX-5 substrates in mycobacteria.

bioRxiv · Sep 11, 2019Microbiology

WhiB6 is required for the secretion-dependent regulation of ESX-1 substrates in pathogenic mycobacteria.

Abdallah M. Abdallah, E.M. Weerdenburg, Qingtian Guan, R. Ummels, S. Borggreve, S.A. Adroub, Tareq B. Malas, Raeece Naeem, Huoming Zhang, T.D. Otto, W. Bitter, A. Pain

This study shows that WhiB6 regulates ESX-1 substrate secretion in mycobacteria, independent of structural components, through transcriptional control and protein interactions.

bioRxiv · May 2, 2018 · PreprintMicrobiology

RD5-mediated lack of PE_PGRS and PPE-MPTR export in BCG vaccine strains results in strong reduction of antigenic repertoire but little impact on protection

L. S. Ates, F. Sayes, W. Frigui, R. Ummels, M. P. M. Damen, D. Bottai, M. A. Behr, W. Bitter, L. Majlessi, R. Brosch

This study shows that BCG vaccine strains lack PE_PGRS/PPE-MPTR export due to RD5 inactivation, reducing antigenic repertoire but not vaccine efficacy.

bioRxiv · Feb 14, 2018Microbiology