Elucidating the viral and host factors enabling the cross-species transmission of primate lentiviruses from simians to humans
D. Tebit, G. Nickel, R. Gibson, C. Carpenter, M. Rodriguez, N. Hathaway, K. Bain, A. Reyes-Rodriguez, J. Bonogo, D. Canaday, D. McDonald, J. Bailey, E. Arts
This study compares the replicative fitness and pathogenicity of 26 primate lentiviruses in human and chimpanzee cells, finding SIVcpz has higher fitness and lower restriction in human cells than HIV-2 lineage strains.
bioRxiv · Oct 13, 2020 · PreprintMicrobiology