D. McDonald

Distinct tissue-niche localization and function of synovial tissue myeloid DC subsets in health, and in active and remission Rheumatoid Arthritis

This study identifies distinct myeloid DC subsets in synovial tissue across health and RA states, showing their roles in inflammation and tolerance.

A stagewise response to mitochondrial dysfunction in mitochondrial DNA maintenance disorders

The paper investigates the cellular response to mitochondrial dysfunction in mtDNA maintenance disorders using imaging mass cytometry, finding complex-specific upregulation and proteostasis activation.

Medication Use is Associated with Distinct Microbial Features in Anxiety and Depression

This study links medication use to distinct gut microbial features in anxiety and depression, showing antidepressants have a larger effect on microbiota than diagnoses.

GBMdeconvoluteR accurately infers proportions of neoplastic and immune cell populations from bulk glioblastoma transcriptomics data

This paper develops GBMdeconvoluteR, a tool to accurately infer neoplastic and immune cell proportions in bulk glioblastoma RNAseq data, validated against imaging mass cytometry.

Rescue of proteotoxic stress and neurodegeneration by the Zn2+ transporter ZIP7

This study shows ZIP7 enhances ERAD by supplying cytosolic Zn2+ for Rpn11 deubiquitination, rescuing vision loss in Drosophila with misfolded rhodopsin.

A condensate forming tether for lariat debranching enzyme is defective in non-photosensitive trichiothiodystrophy

This study identifies TTDN1's role in linking intron lariat processing to the spliceosome, showing its defect causes splicing and gene expression issues in NP-TTD.

Programmed cell death-1 receptor mediated regulation of Tbet+ NK1.1- Innate Lymphoid Cells within the Tumor Microenvironment

This paper identifies Tbet+NK1.1- ILCs in the tumor microenvironment and shows PD-1 regulates their proliferation and anti-tumor function through metabolic changes.

Effects of Variation in Urine Sample Storage Conditions on 16S Urogenital Microbiome Analyses

This study evaluates how urine sample storage conditions affect 16S rRNA gene sequencing results, finding that AssayAssure reduces microbial bias at colder temperatures but not significantly compared to no preservative.

Fish microbiomes 101: disentangling the rules governing marine fish mucosal microbiomes across 101 species

The paper analyzes microbiomes of 101 marine fish species to identify factors influencing microbial diversity and distribution across body sites and environments.

Multi-omic analysis along the gut-brain axis points to a functional architecture of autism

The paper identifies a functional architecture of autism along the gut-brain axis using multi-omic data, revealing microbial and metabolic profiles linked to autism symptoms.

CXCR2 inhibition enables NASH-HCC immunotherapy

This study shows that combining CXCR2 inhibition with anti-PD1 therapy enhances immunotherapy response in NASH-HCC by reprogramming tumor-associated neutrophils.

Multi-omics profiling of Earth's biomes reveals patterns of diversity and co-occurrence in microbial and metabolite composition across environments

The paper performs a multi-omics meta-analysis of microbial and metabolite data from diverse environments, revealing patterns of diversity and co-occurrence across biomes.

High resolution profiling of pathways of escape for SARS-CoV-2 spike-binding antibodies

This study identifies antibody escape pathways for SARS-CoV-2 spike protein using Phage-DMS, revealing variable escape mutations in immunodominant regions and individual epitope targeting differences.

Poised cell circuits in human skin are activated in disease

The paper creates a single-cell atlas of human skin, showing how cell circuits change in inflammatory diseases like atopic dermatitis and psoriasis.

Elucidating the viral and host factors enabling the cross-species transmission of primate lentiviruses from simians to humans

This study compares the replicative fitness and pathogenicity of 26 primate lentiviruses in human and chimpanzee cells, finding SIVcpz has higher fitness and lower restriction in human cells than HIV-2 lineage strains.

Reproductive resilience but not root architecture underpin yield improvement in maize

This study shows that yield improvement in maize is driven by reproductive resilience rather than changes in root architecture or water capture.

Bacterial modification of the host glycosaminoglycan heparan sulfate modulates SARS-CoV-2 infectivity

This study shows that commensal bacteria modify heparan sulfate, reducing SARS-CoV-2 spike protein binding and that this bacterial presence decreases with age, increasing COVID-19 susceptibility.

Age and sex-dependent patterns of gut microbial diversity in human adults

The paper examines age and sex effects on gut microbial diversity across four adult cohorts, finding age-related diversity increases in young adults and sex differences in some groups.

American Gut: an Open Platform for Citizen-Science Microbiome Research

The paper uses citizen-science data to analyze human stool microbiomes, revealing new insights into microbial diversity, metabolome composition, and associations with diet and health.