Author

S. Doyle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Microbiology· 2 Biochemistry· 1 Ecology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 4 Approach:experimental assay· 4 Approach:statistical model· 4 Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. Wahafu· 2 shared C. Shu· 2 shared D. Cicka· 2 shared D. Fan· 2 shared H. Fu· 2 shared Q. Niu· 2 shared T. Owonikoko· 2 shared W. Zhou· 2 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

A. Wahafu

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Allele specific PCR for a major marker of levamisole resistance in Haemonchus contortus

A. Antonopoulos, S. Doyle, D. J. Bartley, A. A. Morrison, R. Kaplan, S. Howell, C. Neveu, V. Busin, E. Devaney, R. Laing

This study develops an allele-specific PCR assay to detect the S168T SNP in acr-8, a marker of levamisole resistance in Haemonchus contortus, and validates it in laboratory and field samples.

bioRxiv · Apr 8, 2022Microbiology

Production of a functionally active recombinant SARS-CoV-2 (COVID-19) 3C-Like protease and a soluble inactive 3C-like protease-RBD chimeric in a prokaryotic expression system

C. De Marco Verissimo, J. Lopez-Corrales, A. L. Dorey, K. Cwiklinski, R. Lalor, N. E. D. Calvani, H. L. Jewhurst, S. Doyle, J. P. Dalton

This paper describes the production of a functionally active SARS-CoV-2 3CL-pro and a soluble 3CLpro-RBD chimeric protein in E. coli, showing improved RBD antigenicity and potential for vaccine development.

bioRxiv · Mar 25, 2022Biochemistry

Systematic discovery of mutation-directed neo-protein-protein interactions in cancer

X. Mo, Q. Niu, A. A. Ivanov, Y. H. Tsang, C. Tang, C. Shu, A. Wahafu, S. Doyle, D. Cicka, X. Yang, D. Fan, M. A. Reyna, L. A. D. Cooper, C. S. Moreno, W. Zhou, , H. Fu

The paper identifies mutation-directed neo-protein-protein interactions in cancer using a high-throughput screening platform, revealing therapeutic opportunities through neo-interaction rewiring.

bioRxiv · Oct 3, 2021Cancer Biology

Pharmacological rescue of tumor intrinsic STING expression and immune response in LKB1-mutant lung cancer via the IAP-JAK regulatory axis

C. Shu, R. Jin, Q. Niu, D. Cicka, S. Doyle, A. Wahafu, D. Fan, X. Zheng, Y. Du, A. Ivanov, D. Doxie, K. Dhodapkar, J. Carlisle, T. Owonikoko, S. Ramalingam, , H. Fu

The paper identifies IAP inhibitors as sensitizers that restore immune response in LKB1-mutant lung cancer by reactivating the STING pathway and enhancing immune infiltration.

bioRxiv · Sep 17, 2021 · PreprintCancer Biology

Targeting methionine synthase in a fungal pathogen causes a metabolic imbalance that impacts cell energetics, growth and virulence

J. Scott, M. Sueiro-Olivares, B. P. Thornton, R. A. Owens, H. Muhamadali, R. Fortune-Grant, D. Thomson, R. Thomas, K. Hollywood, S. Doyle, R. Goodacre, L. Tabernero, E. Bignell, J. Amich

This paper identifies methionine synthase as a promising antifungal target by showing its essentiality in Aspergillus fumigatus and validates its druggability using a genetic model of established infections.

bioRxiv · Jun 4, 2020Microbiology

Vaccine-induced ICOS+CD38+ cTfh are sensitive biosensors of age-related changes in inflammatory pathways

R. S. Herati, L. V. Silva, L. A. Vella, A. Muselman, C. Alanio, B. Bengsch, R. Kurupati, S. Kannan, S. Manne, A. Kossenkov, D. Canaday, S. Doyle, H. Ertl, K. Schmader, E. J. Wherry

The paper uses transcriptional profiling to show that vaccine-induced ICOS+CD38+ cTfh cells in elderly show inflammation-related gene signatures and age-associated biological changes.

bioRxiv · Jul 24, 2019 · PreprintImmunology

The food web of Potter Cove (Antarctica): complexity, structure and function

T. I. Marina, V. Salinas, G. Cordone, G. Campana, M. E. Moreira, D. Deregibus, L. Torre, R. Sahade, M. Tatian, E. Barrera Oro, M. De Troch, S. Doyle, M. L. Quartino, L. Saravia, F. R. Momo

The paper analyzes the food web structure and complexity of Potter Cove, finding low linkage density and connectance, suggesting potential fragility and trophic cascade effects.

bioRxiv · Oct 20, 2017Ecology