Induction of the nicotinamide riboside kinase NAD+ salvage pathway in skeletal muscle of H6PDH KO mice
C. L. Doig, A. E. Zielinska, L. A. Oakey, R. S. Fletcher, Y. S. El Hassan, A. Garten, D. Cartwright, S. Heising, A. Alsheri, D. G. Watson, J. Adamski, D. A. Tennant, G. G. Lavery
This study examines the metabolic and mitochondrial adaptations in H6PDH knockout mice, showing activation of the NRK2 NAD+ salvage pathway and its limited effect on mitigating myopathy and mitochondrial dysfunction.
bioRxiv · Apr 5, 2019 · PreprintPhysiology