M. Super

Identification of pharmacological inducers of a reversible hypometabolic state for whole organ preservation

The paper identifies SNC80 as a drug that reversibly slows metabolism in Xenopus and demonstrates its cross-species applicability in human organs-on-chips and porcine organs.

Enhancers of host immune tolerance to bacterial infection discovered using linked computational and experimental approaches

The paper identifies host tolerance mechanisms to bacterial infection using a Xenopus model and multi-omics analysis, finding that metal chelators and HIF-1 agonists enhance survival.

Harnessing Colon Chip technology to identify commensal bacteria that promote host tolerance to infection

The paper uses a microfluidic organ-on-a-chip model to identify commensal bacteria that enhance host tolerance to infection, finding Enterococcus faecium promotes tolerance.

A rapidly adaptable biomaterial vaccine for SARS-CoV-2

This study develops a biomaterial vaccine using mesoporous silica rods to deliver SARS-CoV-2 antigens and adjuvants, showing rapid antibody responses and neutralizing activity.

Modular biomaterials vaccine technology protects against multiple pathogens and septic shock

The paper introduces a modular vaccine technology (ciVAX) that protects against multiple pathogens and septic shock by using inactivated bacteria and biomaterial scaffolds.

Species-specific enhancement of enterohemorrhagic E. Coli pathogenesis mediated by microbiome metabolites

The paper identifies human gut microbiome metabolites that enhance EHEC pathogenesis in a human colonic organ chip model, contributing to species-specific susceptibility.

Broad spectrum capture of clinical pathogens using engineered Fc-Mannose-Binding Lectin (FcMBL) enhanced by antibiotic treatment

This study demonstrates that FcMBL binds to 86% of pathogen isolates and 90% of pathogen species, including bacteria, fungi, viruses, and parasites, and antibiotic treatment enhances its binding efficiency.