CDKN1B (p27kip1) enhances drug tolerant persister CTCs by restricting polyploidy following mitotic inhibitors.
E. Horwitz, T. D. Dubash, A. Szabolcs, B. S. Wittner, J. Kreuzer, R. Morris, A. Bardia, B. Chirn, D. Wiley, D. Che, H. C. Russel, X. I. H. Lopez, D. B. Fox, E. Antmen, D. T. Ting, , D. A. Haber
This study identifies CDKN1B as a regulator of drug-tolerant persister CTCs by preventing polyploidy after mitotic inhibitor treatment in breast cancer.
bioRxiv · Feb 20, 2024 · PreprintCancer Biology