B. Cui

Therapeutic Peptide SS-31 Modulates Membrane Binding and Aggregation of Alpha-Synuclein and Restores Impaired Mitochondrial Function

This study shows SS-31 reduces alpha-synuclein membrane binding, aggregation, and mitochondrial dysfunction in neuroblastoma cells.

Membrane Curvature Promotes ER-PM Contact Formation via Junctophilin-EHD Interactions

This study shows PM curvature promotes ER-PM contact formation in cardiomyocytes via junctophilin-EHD interactions.

The long-chain fatty acid-CoA ligase FadD1 monitors Pseudomonas aeruginosa quorum sensing as a receptor of cis-2-decenoic acid

This paper identifies FadD1 as a receptor for cis-DA quorum sensing in P. aeruginosa, showing it regulates virulence and physiology by binding cis-DA and modulating gene expression.

High throughput screening of Leaf Economics traits in six wine grape varieties

This study uses reflectance spectroscopy and PLSR to predict leaf traits in six wine grape varieties, finding strong predictions for some traits but not others.

Endoplasmic reticulum exit sites are segregated for secretion based on cargo size

The paper shows that ERES segregate based on cargo size, with bulky cargoes accumulating less at stalled ERES compared to small molecules.

Targeting CD74-positive macrophages improves neoadjuvant therapy in cervical cancer as revealed by single-cell transcriptomics analysis

This study uses single-cell transcriptomics to show that targeting CD74-positive macrophages enhances neoadjuvant therapy efficacy in cervical cancer by altering tumor microenvironment interactions.

Targeted Protein Relocalization via Protein Transport Coupling

This paper demonstrates targeted protein relocalization using shuttle proteins and small molecules to redistribute disease-associated proteins and alleviate cellular stress and neurodegeneration.

Actin-Driven Nanotopography Promotes Stable Integrin Adhesion Formation in Developing Tissue

The paper shows that actin-driven membrane protrusions create nanotopographies that enable stable integrin adhesion in Drosophila muscle attachment sites.

Tumor-derived exosomal miR-222-3p induce cancer-associated fibroblasts activation to foster progression of renal cancer

This study shows that tumor-derived exosomal miR-222-3p activates fibroblasts to promote renal cancer progression by inducing metabolic changes and cytokine secretion.

Engineering cell and nuclear morphology on nano topography by contact-free protein micropatterning

This study uses laser-assisted micropatterning to engineer cell and nuclear morphology on nanopillar platforms, showing disrupted nuclear-cell shape coupling and enhanced endocytosis on nanopillars.

Curved adhesions mediate cell attachment to soft matrix fibres in 3D

This study identifies curved adhesions as a new type of integrin-mediated adhesion that forms in soft matrices and is crucial for 3D cell migration.

Nanometer-Resolution Long-term Tracking of Single Cargos Reveals Dynein Motor Mechanisms

This study uses single-particle tracking to analyze dynein motor behavior in live neurons, revealing that dynein switches between 1-5 motors and requires 2 ATP hydrolysis per step.

Deep-Learning Super-Resolution Microscopy Reveals Nanometer-Scale Intracellular Dynamics at the Millisecond Temporal Resolution

This paper introduces a deep learning method for single-frame super-resolution microscopy, enabling live-cell imaging at nanometer-scale spatial and millisecond temporal resolutions.

Nanocrown electrodes for reliable and robust intracellular recording of cardiomyocytes and cardiotoxicity screening

This paper develops nanocrown electrodes for reliable intracellular recording of cardiomyocytes and demonstrates their use in cardiotoxicity screening.

Exploring cell surface-nanopillar interactions with 3D super-resolution microscopy

This paper introduces a 3D single-molecule super-resolution microscopy method to study protein distribution at the nano-bio interface with 10-20 nm precision.

Nanoscale surface topography reduces focal adhesions and cell stiffness by enhancing integrin endocytosis

This paper shows that nanoscale surface topography reduces focal adhesions and cell stiffness by enhancing integrin endocytosis, mimicking the effects of soft substrates on rigid materials.

Abundant and rare bacterial taxa structuring differently in sediment and water in thermokarst lakes in the Yellow River Source area, Qinghai-Tibet Plateau

This study compares bacterial communities in sediment and water of thermokarst lakes, finding distinct differences in diversity and community structure, with rare taxa showing stronger environmental structuring.

Pericyte-to-endothelial cell signaling via vitronectin-integrin regulates blood-CNS barrier

This study identifies vitronectin-integrin signaling as a mechanism by which pericytes regulate blood-CNS barrier integrity through inhibition of transcytosis in endothelial cells.

Brucella outer membrane proteins to control maturation and antigen presentation of mouse dendritic cells

This study examines how Brucella outer membrane proteins and mutants affect dendritic cell maturation and antigen presentation in mice, revealing their roles in immune evasion and pathogenesis.

The virus integrations in gut microbes associated with dysbiosis of microbial community in tumorigenesis of colorectal carcinoma

This study identifies viral genetic integrations in gut microbes associated with microbial dysbiosis in colorectal carcinoma tumorigenesis.

Development of CRISPR-Cas13a-based antimicrobials capable of sequence-specific killing of target bacteria

This study develops CRISPR-Cas13a-based antimicrobials that kill target bacteria by cleaving RNA, showing effectiveness against carbapenem-resistant E. coli and methicillin-resistant S. aureus.

Magnetic manipulation of axonal endosome transport in live neurons

This paper introduces a method to control axonal endosome transport in live neurons using magnetic forces, revealing insights into dynein function and endosome dynamics.

Composition and Diversity of CRISPR-Cas13a systems in the genus Leptotrichia

The paper analyzes CRISPR-Cas13a and other CRISPR-Cas systems in 11 Leptotrichia strains, revealing their diversity, distribution, and evolutionary relationships.

Nanoscale investigation in 3D scaffolds of cell-material interactions for tissue-engineering

The paper investigates cell-material interactions in 3D scaffolds using SEM/FIB to better understand cellular adhesion and guide tissue-engineering design.

Revealing The Cell-Material Interface With Nanometer Resolution By FIB-SEM

This paper introduces a method to visualize the cell-material interface at nanometer resolution using FIB-SEM, enabling detailed study of cell-material interactions.

Nanoscale Manipulation Of Membrane Curvature For Probing Endocytosis In Live Cells

This study uses nanostructured substrates to control membrane curvature in live cells and finds that CME proteins prefer positive curvature, while other proteins do not.