C. Xie

Artificial Intelligence-Enabled AlphaFold II Pipeline Guides Functional Fluorescence Labeling of Tubulin Across Species

The paper develops an AI-driven method to label tubulin isotypes in vivo across species, enabling precise visualization of microtubule dynamics and pathogenic variants without disrupting cellular processes.

Armored Bicistronic CAR T Cells with Dominant-negative TGF-β Receptor II to Overcome Resistance in Glioblastoma.

This paper develops a tri-modular CAR T cell construct with a dominant-negative TGF-β receptor II to overcome GBM resistance by enhancing T cell function and efficacy in a preclinical model.

The Gut Microbiome Controls Liver Tumors via the Vagus Nerve

This study shows that gut microbiota influence liver tumor growth and behavior through the vagus nerve, with cholinergic signaling and CD8+ T cells playing key roles.

Inhibiting YAP1 reduced abdominal aortic aneurysm formation by suppressing adventitial fibroblast phenotype transformation and migration

This study shows that inhibiting YAP1 reduces abdominal aortic aneurysm formation by preventing adventitial fibroblast transformation into myofibroblasts and migration.

Evolution of resistance to KRASG12C inhibitor in a non-small cell lung cancer responder

This study tracks immune cell changes in a KRASG12C NSCLC patient during sotorasib treatment and resistance, showing fluctuations in CD8+CD161hi T cells.

Lithocholic acid targets TULP3 to activate sirtuins and AMPK to retard ageing

This study identifies LCA's mechanism of action through TULP3-sirtuin-v-ATPase-AMPK pathway to activate AMPK and extend lifespan in model organisms.

A semi-automated cell tracking protocol for quantitative analyses of neutrophil swarming to sterile and S. aureus contaminated bone implants in a mouse femur model

This paper develops a semi-automated cell tracking protocol to quantify neutrophil swarming in a mouse femur model with and without S. aureus infection, showing increased speed, displacement, and directionality in infected mice.

ARF6 as a novel activator of HIF-2alpha in pulmonary arterial hypertension

This study identifies ARF6 as a novel activator of HIF-2alpha in pulmonary arterial hypertension and shows that the antibiotic CTC inhibits this pathway.

Expansion Strategy-Driven Micron-Level Resolution Mass Spectrometry Imaging of Lipids in Mouse Brain Tissue

This paper introduces a method to enhance spatial resolution in lipid mass spectrometry imaging of mouse brain tissue by using a swellable polyelectrolyte gel, achieving subcellular-level visualization.

Decorin suppresses tumor lymphangiogenesis: A mechanism to curtail cancer progression

This study shows decorin suppresses tumor lymphangiogenesis by inhibiting VEGFR3 and reducing lymphatic vessel markers, suggesting it as a potential therapeutic for breast cancer.

Distinct Microstructural Heterogeneities Underpin Specific Micromechanical Properties in Human ACL Femoral and Tibial Entheses

This study identifies distinct microstructural and biomolecular features in ACL femoral and tibial entheses that contribute to their specific mechanical properties.

AMPK targets PDZD8 to trigger carbon source shift to glutamine

This paper identifies AMPK's role in shifting carbon utilization from glucose to glutamine via PDZD8 phosphorylation, enhancing glutaminolysis and extending lifespan in C. elegans and mice.

Cardiac Effects of a Novel pH-Insensitive Sodium-Calcium Exchanger Mouse

This study creates a pH-insensitive NCX1 mouse and finds it has reduced growth, accelerated cardiac repolarization, and is resistant to ischemia/reperfusion injury.

Biomaterial based implants caused remote liver fatty deposition through activated blood-derived Kupffer cells

Abdominal biomaterial implantation induces remote organ fatty deposition via activated blood-derived Kupffer cells.

Endothelial cell-derived lactate triggers mesenchymal stem cell histone lactylation to attenuate osteoporosis

This study shows that endothelial cell lactate promotes BMSC histone lactylation, enhancing osteogenesis and reducing osteoporosis, with exercise increasing lactate to alleviate the condition.

Cyclic di-GMP interact with putrescine via a PilZ domain receptor YcgR

This study shows that c-di-GMP interacts with putrescine via the YcgR receptor to regulate bacterial motility in Dickeya oryzea, with c-di-GMP inhibiting putrescine's effect.

Pangenome-based dynamic trajectories of intracellular gene transfers in Poaceae unveil a high rate of unceasing integration and selective retention in Triticeae

This study maps the dynamic trajectories of intracellular gene transfers in Poaceae using a novel tool, revealing lineage-specific patterns and functional roles of nuclear organelle genes.

The protozoan commensal Tritrichomonas musculis is a natural adjuvant for mucosal IgA.

This study shows that the protozoan commensal Tritrichomonas musculis promotes T-cell dependent IgA class-switch recombination and enhances IgA-secreting plasma cell accumulation and dissemination.

Significantly amplified photoacoustic effect for silica-coated gold nanoparticles by interface heat transfer mechanisms

This study demonstrates a 4-fold photoacoustic amplification in silica-coated gold nanoparticles using picosecond laser excitation, attributed to interface heat transfer mechanisms.

Chiral Derivatization-enabled Discrimination and Visualization of Proteinogenic Amino Acids by Ion Mobility Mass Spectrometry

This paper develops a method using chiral derivatization and TIMS-MS to separate and visualize 19 pairs of chiral amino acids in complex biological samples.

Tyrosine phosphorylation tunes chemical and thermal sensitivity of TRPV2 ion channel

This study shows that tyrosine phosphorylation modulates TRPV2's chemical and thermal sensitivity in macrophages through JAK1 and PTPN1.

In vitro and in vivo venom-inhibition assays identify metalloproteinase-inhibiting drugs as potential treatments for snakebite envenoming by Dispholidus typus

This study evaluates four SVMP inhibitors for treating D. typus snakebite envenoming, finding DMPS and marimastat effective in preclinical models.

A magnetic field prevents alcoholic liver disease by reducing oxidative stress

This study shows that a specific static magnetic field reduces oxidative stress and liver damage caused by alcohol consumption in mice.

Nrf2 mediated ER-phagy protects against oxidative damage in intervertebral disc degeneration

This study identifies Nrf2/FAM134B-mediated ER-phagy as a protective mechanism against oxidative damage in intervertebral disc degeneration.

Evolution of a new testis-specific functional promotor within the highly conserved Map2k7 gene of the mouse

The paper identifies a new testis-specific promoter in the conserved Map2k7 gene in M. m. domesticus, showing its role in sperm motility and spermatid transcriptome.

Single Pulse Heating of Nanoparticle Array for Biological Applications

This study develops a computational model to investigate single-pulsed nanoparticle array heating and its effects on protein denaturation and activation, identifying key parameters for targeted protein manipulation.

Therapeutic inhibition of keratinocyte TRPV3 sensory channels by local anesthetic dyclonine

This study shows that dyclonine inhibits TRPV3 channels in keratinocytes, rescuing cell death and reducing pruritus in a mouse model.

Computational investigation of protein photoinactivation by molecular hyperthermia

This study uses a numerical model to investigate parameters affecting protein inactivation via molecular hyperthermia, identifying key factors that influence the impact zone of nanoscale heating.

Precise Localization and Dynamic Distribution of Japanese Encephalitis Virus in theBrain Nuclei of Infected Mice

This study tracks the dynamic localization of Japanese encephalitis virus (JEV) in mouse brain nuclei over time, revealing its progression from thalamus and medulla oblongata to widespread distribution in the central nervous system.

The therapeutic effects of intratumoral injection of IL12IL2GMCSF fusion protein on canine tumors

This study evaluates the therapeutic effects of IL12IL2GMCSF fusion protein in canine tumors, showing significant response rates with minimal adverse effects.