A molecular switch between mammalian MLL complexes dictates response to Menin-MLL inhibition
Y. M. Soto-Feliciano, F. J. Sanchez-Rivera, F. Perner, D. W. Barrows, E. R. Kastenhuber, Y.-J. Ho, T. Carroll, Y. Xiong, D. Anand, A. Soshnev, L. Gates, M. C. Beytagh, D. Cheon, S. Gu, X. S. Liu, , C. D. Allis
The paper identifies a molecular switch between MLL1-Menin and MLL3/4-UTX complexes that determines response to Menin-MLL inhibitors in leukemia.
bioRxiv · Oct 22, 2021Cancer Biology