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Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
11 papers
Recent·Most cited
E. Lee, Z. Zhang, C.-C. Chen, D. Choi, A. C. A. Rivera, E. Linton, Y.-j. Ho, J. Love, J. LaClair, J. Wongvipat, C. Sawyers
This study shows that treatment timing affects the path to androgen receptor signaling inhibitor resistance in prostate cancer, with resistance arising through different mechanisms depending on the tumor context.
bioRxiv · Mar 18, 2024 · PreprintCancer Biology
K. M. Tsanov, F. M. Barriga, Y.-J. Ho, D. Alonso-Curbelo, G. Livshits, R. P. Koche, T. Baslan, J. Simon, S. Tian, A. N. Wuest, W. Luan, J. E. Wilkinson, I. Masilionis, N. Dimitrova, C. A. Iacobuzio-Donahue, , S. W. Lowe
This study shows that metastatic site influences the function of driver genes like SMAD4 in pancreatic cancer, with organ-specific epigenetic states affecting tumor growth.
bioRxiv · Mar 17, 2024 · PreprintCancer Biology
S. R. Torborg, O. Grbovic-Huezo, A. Singhal, M. Holm, K. Wu, X. Han, Y.-J. Ho, C. Haglund, M. J. Mitchell, S. W. Lowe, L. E. Dow, K. L. Pitter, F. J. Sanchez-Rivera, A. Levchenko, T. Tammela
This study identifies a stereotypic organization of pancreatic ductal adenocarcinoma cells based on WNT signaling and Notch ligand interactions, showing that disrupting this equilibrium suppresses tumor growth and metastasis.
bioRxiv · Dec 30, 2023 · PreprintCancer Biology
C. Burdziak, D. Alonso-Curbelo, T. Walle, F. M. Barriga, J. Reyes, Y. Xie, Z. Zhao, C. J. Zhao, H.-A. Chen, O. Chaudhary, I. Masilionis, Z.-N. Choo, V. Gao, W. Luan, A. Wuest, , D. Pe'er
The paper uses single-cell analysis to show that epigenetic plasticity and cell-cell interactions drive tissue remodeling in early pancreatic cancer.
bioRxiv · Jul 26, 2022Cancer Biology
L. Chibaya, K. C. Murphy, Y. Lopez-Diaz, K. D. DeMarco, H. Liu, S. Gopalan, M. Faulkner, J. Li, J. P. Morris, Y.-J. Ho, J. Simon, W. Luan, A. Kulick, E. De Stanchina, K. Simin, , M. Ruscetti
This study shows that inhibiting EZH2 enhances pro-inflammatory SASP in pancreatic cancer, improving NK and T cell infiltration and tumor control in mouse models.
bioRxiv · Jun 21, 2022Cancer Biology
J. Leibold, C. Amor, K. M. Tsanov, Y.-J. Ho, F. J. Sanchez-Rivera, J. Feucht, T. Baslan, H.-A. Chen, S. Tian, J. Simon, A. Wuest, J. E. Wilkinson, S. W. Lowe
This study develops somatic mouse models of gastric cancer that replicate human disease subtypes and reveal genotype-specific metastatic patterns and immune interactions.
bioRxiv · Jun 15, 2022Cancer Biology
Y. M. Soto-Feliciano, C. Zhu, J. P. Morris, C.-h. Huang, R. P. Koche, Y.-j. Ho, A. Banito, C.-w. Chen, A. Shroff, S. Tian, L. Geulah, C.-c. Chen, M. Fennell, S. Armstrong, C. D. Allis, , S. W. Lowe
This study shows that MLL3 regulates the CDKN2A tumor suppressor locus in liver cancer by affecting chromatin modifications and gene expression.
bioRxiv · Jun 7, 2022Cancer Biology
H.-A. Chen, Y.-J. Ho, R. Mezzadra, J. M. Adrover, R. M. Smolkin, C. Zhu, L. Wei, A. Wuest, S. Tian, X. Li, R. C. Hendrickson, M. Egeblad, D. Alonso-Curbelo, S. W. Lowe
The paper shows senescent cells enhance immune surveillance by remodeling their surface proteome to better sense and respond to environmental signals like IFN-gamma.
bioRxiv · Jun 4, 2022Cancer Biology
Y. M. Soto-Feliciano, F. J. Sanchez-Rivera, F. Perner, D. W. Barrows, E. R. Kastenhuber, Y.-J. Ho, T. Carroll, Y. Xiong, D. Anand, A. Soshnev, L. Gates, M. C. Beytagh, D. Cheon, S. Gu, X. S. Liu, , C. D. Allis
The paper identifies a molecular switch between MLL1-Menin and MLL3/4-UTX complexes that determines response to Menin-MLL inhibitors in leukemia.
bioRxiv · Oct 22, 2021Cancer Biology
A. Hayashi, Y.-j. Ho, A. P. Makohon-Moore, A. Zucker, J. Hong, J. G. Reiter, J. Huang, L. Zhang, M. A. Attiyeh, P. Baez, R. Kappagantula, J. P. Melchor, E. M. OReilly, N. D. Socci, S. Oki, , C. A. Iacobuzio-Donahue
This study investigates the evolutionary dynamics of non-coding regions in pancreatic cancer, finding higher mutational burden in noncoding DNA and similar mutational spectra between enhancers and coding DNA.
bioRxiv · Sep 11, 2020 · PreprintCancer Biology
A. Hayashi, J. Fan, R. Chen, Y.-j. Ho, A. P. Makohon-Moore, Y. Zhong, J. Hong, H. Sakamoto, M. A. Attiyeh, Z. A. Kohutek, L. Zhang, J. Huang, A. Boumiza, R. Kappagantula, P. Baez, , C. A. Iacobuzio-Donahue
The paper identifies genetic and transcriptional features of basal-like subtypes in pancreatic ductal adenocarcinoma, linking them to squamous histology and chromatin modifier mutations.
bioRxiv · Apr 4, 2019 · PreprintCancer Biology