T. Carroll

Globally abundant birds disproportionately inhabit anthropogenic environments

The study finds that globally abundant bird species are more likely to inhabit human-modified environments compared to less abundant species.

Administration of vaccine-boosted COVID-19 convalescent plasma to SARS-CoV-2 infected hamsters decreases virus replication in lungs and hastens resolution of the infection despite transiently enhancing disease and lung pathology.

This study shows that vaccine-boosted convalescent plasma reduces SARS-CoV-2 replication in hamsters but temporarily worsens disease and lung pathology.

Chemo-phosphoproteomic profiling with ATR inhibitors berzosertib and gartisertib uncovers new biomarkers and DNA damage response regulators

The paper identifies novel ATR-dependent phospho-proteomic targets and reveals new biomarkers and genome maintenance factors through screening with ATR inhibitors.

Coevolution of the CDCA7-HELLS ICF-related nucleosome remodeling complex and DNA methyltransferases

This study examines the coevolution of CDCA7, HELLS, and DNA methyltransferases, finding that their presence-absence patterns are non-random and linked across species.

A molecular switch between mammalian MLL complexes dictates response to Menin-MLL inhibition

The paper identifies a molecular switch between MLL1-Menin and MLL3/4-UTX complexes that determines response to Menin-MLL inhibitors in leukemia.

The B.1.427/1.429 (epsilon) SARS-CoV-2 variants are more virulent than ancestral B.1 (614G) in Syrian hamsters

This study shows that the B.1.427/1.429 (epsilon) SARS-CoV-2 variants cause more severe disease and higher viral loads in the upper respiratory tract in Syrian hamsters compared to the ancestral B.1 (614G) strain.

Epilepsy kinase CDKL5 is a DNA damage sensor which controls transcriptional activity at DNA breaks

CDKL5 is a DNA damage-sensing kinase that modulates transcriptional activity near DNA breaks.

Human T-bet governs innate and innate-like adaptive IFN-γ immunity against mycobacteria

This study identifies T-bet deficiency as a cause of mycobacterial disease by impairing IFN-γ production in innate and innate-like adaptive lymphocytes.

A histone-like motif in yellow fever virus contributes to viral replication

This study identifies a histone-like motif in the yellow fever virus capsid protein that mimics histone H4 and interferes with BRD4-mediated gene regulation, impacting viral replication.

Independence of HIF1a and androgen signaling pathways in prostate cancer

The paper investigates the relationship between HIF1a and androgen signaling pathways in prostate cancer, finding they operate independently and identify shared genes associated with poor prognosis.

Postmitotic Separation Enables Selective Niche Retention Of One Daughter Cell In Intestinal Crypts And Is Facilitated By Interkinetic Nuclear Migration And Basal Tethering

The paper shows that postmitotic separation of intestinal crypt cells leads to niche retention of one daughter cell, and this process is disrupted in Apc mutant cells.