BiochemistrybioRxiv
3-O-methyltolcapone and Its Lipophilic Analogues are Potent Inhibitors of Transthyretin Amyloidogenesis with High Permeability and Low Toxicity
T. Poonsiri, D. dell Accantera, V. Loconte…·M. Cianci
This study identifies 3-O-methyltolcapone and its lipophilic analogs as potent TTR stabilizers with improved permeability and reduced toxicity compared to tolcapone.
DOI 10.3390/ijms25010479