A. Ferrari

EigenBrain maps cortical molecular architecture from functional, geometric, and structural eigenmodes

The paper shows functional MRI eigenmodes can approximate specific receptor and transporter distributions in the cortex, while structural and geometric eigenmodes cannot, and applies this to detect molecular differences in autism and schizophrenia.

Glacier retreat decreases plant-pollinator network robustness over space-time

This study examines how glacier retreat affects plant-pollinator network structure and robustness, finding shifts toward generalist interactions and reduced network stability.

T cell cholesterol transport is a metabolic checkpoint that links intestinal immune responses to dietary lipid absorption

This study identifies Aster-A as a cholesterol transporter in T cells that regulates immune signaling and metabolic responses by controlling membrane cholesterol levels.

Second Boost of Omicron SARS-CoV-2 S1 Subunit Vaccine Induced Broad Humoral Immune Responses in Elderly Mice

This study shows that a second booster dose of an Omicron S1 subunit vaccine enhances broad humoral immunity and cross-neutralizing antibodies in elderly mice.

3-O-methyltolcapone and Its Lipophilic Analogues are Potent Inhibitors of Transthyretin Amyloidogenesis with High Permeability and Low Toxicity

This study identifies 3-O-methyltolcapone and its lipophilic analogs as potent TTR stabilizers with improved permeability and reduced toxicity compared to tolcapone.

Fourth dose of Microneedle Array Patch of SARS-CoV-2 S1 Protein Subunit Vaccine Elicits Robust Long-lasting Humoral Responses in mice

This study evaluates a microneedle array patch-based S1 subunit vaccine in mice, showing that four doses induce robust, long-lasting immune responses against multiple SARS-CoV-2 variants.

Aster-dependent non-vesicular transport facilitates dietary cholesterol uptake

The paper identifies the Aster pathway as critical for dietary cholesterol uptake and shows it can be targeted with a small molecule inhibitor.

Tetravalent SARS-CoV-2 S1 Subunit Protein Vaccination Elicits Robust Humoral and Cellular Immune Responses in SIV-Infected Rhesus Macaque Controllers

This study evaluates a tetravalent SARS-CoV-2 S1 subunit vaccine in SIV-infected rhesus macaques, showing robust humoral and cellular immune responses, including cross-reactivity against Omicron.

SARS-CoV-2 S1 Subunit Booster Vaccination Elicits Robust Humoral Immune Responses in Aged Mice

This study shows that a S1 subunit booster vaccine enhances neutralizing antibodies and cross-reactivity against multiple SARS-CoV-2 variants in aged mice vaccinated with an adenovirus-based vaccine.

Strandings of loggerhead sea turtles south of the Po River delta: insights from a highly impacted area

This study analyzes loggerhead sea turtle strandings along a 18 km coast in Italy, identifying July as the critical month and trawl fishery interaction as the main mortality cause.

Force-biased nuclear import sets nuclear-cytoplasmic volumetric coupling by osmosis

The paper measures cytoplasmic and nuclear volumes in human cells and finds cytoplasm grows exponentially while nucleus grows linearly, showing cytoskeletal forces influence nuclear import and volumetric coupling via osmosis.

PIP4K2B is a mechanosensor and induces heterochromatin-driven nuclear softening through UHRF1.

The paper identifies PIP4K2B as a mechanosensor that induces nuclear softening via UHRF1, affecting YAP activity and cell motility in cancer.

Immunity to SARS-CoV-2 up to 15 months after infection

This study tracks SARS-CoV-2 immunity in patients up to 15 months post-infection, showing sustained antibody and memory B/T cell responses but reduced neutralization against variants.

Harnessing the power of metabarcoding in the ecological interpretation of plant-pollinator DNA data: strategies and consequences of reads filtering

This study evaluates the impact of different read filtering strategies on ecological interpretations of DNA metabarcoding data from plant-pollinator interactions.

Partially methylated domains are hypervariable in breast cancer and fuel widespread CpG island hypermethylation

The paper shows PMDs are hypervariable in breast cancer and drive CGI hypermethylation, but do not significantly repress cancer genes.