D. F. Wirth

Artemisinin resistance mutations in Pfcoronin impede hemoglobin uptake

This study identifies Pfcoronin mutations as a mechanism of artemisinin resistance by impairing hemoglobin uptake in Plasmodium falciparum.

Collateral sensitivity as a strategy to suppress resistance emergence: the challenge of diverse evolutionary pathways

This study investigates collateral sensitivity between DHODH inhibitors to suppress malaria resistance, finding that cross-resistant mutants can emerge despite initial sensitivity.

P. falciparum gametocyte density and infectivity in peripheral blood and skin tissue of naturally infected parasite carriers

The paper investigates whether P. falciparum gametocytes are sequestered in skin tissue and finds no significant skin sequestration, showing peripheral blood gametocyte densities predict mosquito infection.

Detection of low-density Plasmodium falciparum infections using amplicon deep sequencing

This paper evaluates four amplicon sequencing tools for detecting low-density Plasmodium falciparum infections, finding they can detect down to 5 genomes/l but have reduced accuracy at very low parasitemia.

Within-infection diversity of Plasmodium falciparum antigens reflects host-mediated selection

The paper analyzes intra-host diversity of Plasmodium falciparum antigens in sub-Saharan Africa to show host immunity influences which parasite strains progress to the blood stage.