T. Bousema

Modulation of host signalling pathways reveal a major role for Wnt signalling in the maturation of Plasmodium falciparum liver schizonts

The paper identifies Wnt signaling as critical for Plasmodium falciparum liver schizont maturation by using a novel medium to maintain hepatocyte functionality and analyze host-parasite interactions.

Reversible host cell surface remodelling limits immune recognition and maximizes transmission of Plasmodium falciparum gametocytes

This study shows that surface remodelling in Plasmodium falciparum gametocytes helps evade immune detection and facilitates transmission by controlling their sequestration and release into the bloodstream.

AlbuMAX supplemented media induces the formation of transmission-competent P. falciparum gametocytes

This study shows that AlbuMAX supplemented media increases the production of transmission-competent Plasmodium falciparum gametocytes compared to serum.

Target-agnostic identification of human antibodies to Plasmodium falciparum sexual forms reveals cross stage recognition of glutamate-rich repeats

The paper identifies human antibodies targeting Plasmodium falciparum sexual stages, revealing cross-stage recognition of glutamate-rich repeats through a novel method.

Quantification of sporozoite expelling by Anopheles mosquitoes infected with laboratory and naturally circulating P. falciparum gametocytes

The paper quantifies sporozoite expulsion from Anopheles mosquitoes infected with P. falciparum gametocytes, finding that infection burden correlates with sporozoite expulsion.

Plasmodium falciparum adapts its investment into replication versus transmission according to the host environment

The paper shows that Plasmodium falciparum adjusts its investment between replication and transmission based on host factors and changing transmission environments.

Number and proportion of P. falciparum gametocytes vary from acute infection to chronic parasite carriage despite unaltered sexual commitment rate

The paper compares gametocyte levels and sexual commitment in P. falciparum infections during dry and wet seasons, finding increased mature gametocytes in asymptomatic dry season carriers without changes in sexual commitment.

Artemisinin-independent inhibitory activity of Artemisia sp. infusions against different Plasmodium stages including relapse-causing hypnozoites

This study shows that Artemisia infusions inhibit Plasmodium stages without artemisinin, suggesting potential for new antimalarial compounds.

Anopheles stephensi as an emerging malaria vector in the Horn of Africa with high susceptibility to Ethiopian Plasmodium vivax and Plasmodium falciparum isolates

The paper assesses the susceptibility of Anopheles stephensi to Ethiopian Plasmodium vivax and P. falciparum isolates, finding high receptivity and potential for increased malaria transmission in the Horn of Africa.

P. falciparum gametocyte density and infectivity in peripheral blood and skin tissue of naturally infected parasite carriers

The paper investigates whether P. falciparum gametocytes are sequestered in skin tissue and finds no significant skin sequestration, showing peripheral blood gametocyte densities predict mosquito infection.

Probabilistic data integration identifies reliable gametocyte-specific proteins and transcripts in malaria parasites

The paper integrates omics data to identify gametocyte-specific genes and transcripts in malaria parasites, finding novel biomarkers and validating their expression in natural infections.