Secreted cytokines provide local immune tolerance for human stem cell-derived islets
D. Gerace, Q. Zhou, J. H.-R. Kenty, E. Sintov, X. Wang, K. R. Boulanger, H. Li, D. Melton
This study shows that engineering human stem cell-derived islets to secrete tolerogenic cytokines can prevent xeno-rejection without immunosuppression or encapsulation.
bioRxiv · May 9, 2022 · PreprintBioengineering