Q. Zhou

Targeting NOTCH2-JAG1 juxtacrine signaling reverses macrophage-mediated tumor resistance to taxol

This study identifies NOTCH2-JAG1 juxtacrine signaling as a target to reverse macrophage-mediated taxane resistance in ovarian cancer by sensitizing tumors to paclitaxel.

Decoding the anti-aging effect of retinol in reshaping the human skin microbiome niches

This study investigates how retinol affects the human skin microbiome and its role in retinol's anti-aging effects using phenomics, metagenomics, and metabolomics.

Multiomics mapping and characterization of cellular senescence in aging human skeletal muscle uncovers a novel senotherapeutic for sarcopenia

This study uses single-nucleus multiomics to characterize senescence in human skeletal muscle, identifies SASP factors, and proposes Maraviroc as a senotherapeutic for sarcopenia.

Filament structures unveil the dynamic organization of human acetyl-CoA carboxylase

The paper determines cryo-EM structures of human ACC1 in inactive and activated states, revealing structural dynamics and regulatory mechanisms.

IL-4 Licenses B Cell Activation Through Cholesterol Synthesis

This study shows IL-4 promotes B cell activation by upregulating cholesterol synthesis, which is essential for ER expansion, cell cycle progression, and proliferation during influenza infection.

Structural insights into human propionyl-CoA carboxylase (PCC) and 3-methylcrotonyl-CoA carboxylase (MCC)

The paper reports high-resolution cryo-EM structures of human PCC and MCC, revealing substrate binding modes and biotin coordination mechanisms.

Validation of ferroptosis in canine cancer cells to enable comparative oncology and translational medicine

This study validates ferroptosis in canine cancer cells, showing similar responses to human cells, supporting dogs as a model for developing ferroptosis-based cancer therapies.

The Transcription Factor OsNAC5 Mediates Cadmium Stress Response and Accumulation in Rice

This study identifies OsNAC5 as a transcription factor that regulates Cd uptake in rice by activating OsNRAMP1, reducing Cd accumulation in grains.

Soft-lithographically defined template for arbitrarily patterned acoustic bioassembly

This paper introduces a soft-lithography-based acoustic bioassembly technique to create complex multicellular structures with functional liver tissue mimic capabilities.

Extracellular electron transfer drives efficient H2-independent methylotrophic methanogenesis by Methanomassiliicoccus, a seventh order methanogen

This study shows Methanomassiliicoccus uses extracellular electron transfer for efficient methylotrophic methanogenesis, enhancing methane production in coculture with electrogenic bacteria.

The synergistic effects of plants and nitrogen on microbial hitchhiking

The paper investigates how plants and nitrogen fertilizer influence microbial hitchhiking, finding that their synergy affects soil microbiome composition and function depending on nitrogen levels.

Cell circuits underlying nanomaterial specific respiratory toxicology

This study uses single-cell RNA-sequencing to analyze how different nanomaterials affect lung inflammation in mice, identifying cell type-specific responses and mechanisms.

Transcriptomic interplay between Acinetobacter baumannii, human macrophage and polymyxin

This study uses dual RNA-sequencing to analyze transcriptomic changes in Acinetobacter baumannii and human macrophages under polymyxin B treatment, revealing key stress response mechanisms and potential therapeutic targets.

A basally active cGAS-STING pathway limits SARS-CoV-2 replication in a subset of ACE2 positive airway cell models

This study identifies tonic activation of the cGAS-STING and IFN pathways in ACE2-positive airway cells as a factor limiting SARS-CoV-2 replication.

ARBUR, a machine learning-based analysis system for relating behaviors and ultrasonic vocalizations of rats

ARBUR is a machine learning system that clusters rat ultrasonic vocalizations and detects social behaviors, revealing communication patterns and novel findings in social interactions.

Identification of avaC from infant gut microbial isolates that convert 5AVA to 2-piperidone with high efficiency

This study identifies gut bacterial strains and the gene avaC that efficiently convert 5AVA to 2-piperidone, with implications for disease risk prediction and industrial biosynthesis.

Mucosal Adenoviral-vectored Vaccine Boosting Durably Prevents XBB.1.16 Infection in Nonhuman Primates

This study shows that mucosal adenoviral-vectored vaccines provide durable protection against XBB.1.16 infection in nonhuman primates, outperforming intramuscular boosting in reducing virus replication in both upper and lower airways.

Induction of immortal-like and functional CAR-T cells by defined factors

This study identifies factors that induce CAR-T cells with stem-like properties, enhancing their long-term persistence and antitumor efficacy in vivo.

Recurrent hybridization and gene flow shaped Norway and Siberian spruce evolutionary history over multiple glacial cycles

This study examines the evolutionary history of Norway and Siberian spruce, revealing recurrent hybridization and gene flow across glacial cycles, with distinct genetic clusters and refugia shaping their distribution.

Rapid measurement and statistical ranking of leaf drought tolerance capacity in cotton

This study develops a Bayesian hierarchical model to rapidly measure and statistically rank cotton drought tolerance using leaf dry matter content and osmotic potential data from field trials.

Von Willebrand Factor Synergizes with Tumor-Derived Extracellular Vesicles to Promote Gastric Cancer Metastasis

This study shows that von Willebrand factor (VWF) and gastric cancer-derived extracellular vesicles (gcEVs) work together to promote metastasis by disrupting endothelial integrity and facilitating cancer cell migration.

Flavinated SDHA Underlies the Change in Intrinsic Optical Properties of Oral Cancers

The paper identifies flavinated SDHA as responsible for altered autofluorescence in oral cancer cells, linking it to metabolic changes and potential diagnostic and therapeutic targets.

SALLB not targeted by IMiDs is important for maintenance of liver cancer cells

The paper identifies a compound that degrades both SALL4 isoforms, overcoming IMiD limitations in liver cancer treatment.

A Novel Angiogenesis Role of GLP-1(32-36) to Rescue Diabetic Ischemic Lower Limbs via GLP-1R-Dependent Glycolysis

This study identifies GLP-1(32-36) as a therapeutic agent that rescues diabetic ischemic lower limbs by enhancing glycolysis and EPC function via GLP-1R-dependent mechanisms.

Skin permeable polymer for noninvasive transdermal insulin delivery

This paper develops a polymer, OPDMA, that enables noninvasive transdermal insulin delivery in diabetic mice and minipigs, achieving hypoglycemic effects comparable to subcutaneous injection.

Assessing Genetic Diversity in Critically Endangered Chieniodendron hainanense Populations within Fragmented Habitats in Hainan

This study assesses genetic diversity in critically endangered Chieniodendron hainanense populations using GBS and SNP methods, finding limited diversity and weak genetic differentiation.

Lattice-Boltzmann Modelling for Inertial Particle Microfluidics Applications -- A Tutorial Review

This paper reviews lattice-Boltzmann methods for simulating inertial particle microfluidics applications, providing a guide and case studies.

Maintaining hypoxia environment of subchondral bone alleviates osteoarthritis progression

This study shows that inhibiting subchondral osteoclastogenesis maintains hypoxia in subchondral bone, slowing osteoarthritis progression by stabilizing HIF-1 and reducing cartilage degeneration.

Single-shot 3D photoacoustic tomography using a single-element detector for ultrafast imaging of hemodynamics

This paper introduces a single-shot 3D photoacoustic tomography method using a single-element detector to enable ultrafast hemodynamics imaging in humans and small animals.

A non-canonical function of LDHB promotes SLC7A11-mediated glutathione metabolism and protects against glutaminolysis-dependent ferroptosis in KRAS-driven lung cancer

This study identifies a non-canonical role of LDHB in protecting KRAS-driven lung cancer from ferroptosis by promoting SLC7A11-mediated glutathione metabolism.