Host poly(A) polymerases PAPD5 and PAPD7 provide two layers of protection that ensure the integrity and stability of hepatitis B virus RNA
F. Liu, A. C. H. Lee, F. Guo, A. S. Kondratowicz, H. M. Micolochick Steuer, A. Miller, L. D. Bailey, X. Wang, S. Chen, S. G. Kultgen, A. Cuconati, A. G. Cole, D. Gotchev, B. D. Dorsey, R. Rijnbrand, , M. Gao
This study investigates how PAPD5 and PAPD7 stabilize HBV RNA and shows that PAPD5 is dominant in protecting the poly(A) tail, while PAPD7 acts as a backup mechanism.
bioRxiv · Apr 12, 2021Microbiology